Prevalence of raised body mass index in paediatric sickle cell disease.

Autor: Jackson E; Division of Pediatric Hematology Oncology, University of Mississippi Medical Center, Jackson, Mississippi, United States., Karlson CW; Division of Pediatric Hematology Oncology, University of Mississippi Medical Center, Jackson, Mississippi, United States.; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, United States., Herring W; Mississippi Center for Advanced Medicine, Jackson, Mississippi, United States., Okhomina VI; Department of Data Science, University of Mississippi Medical center, Jackson, Mississippi, United States., Lim CS; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi, United States., Morrow A; Department of Psychology, Florida International University, Miami, Florida, United States.; College of Psychology, Nova Southeastern University, Fort Lauderdale, Florida, United States., Daggett C; School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, United States., Arnold L; Division of Pediatric Hematology Oncology, University of Mississippi Medical Center, Jackson, Mississippi, United States., McNaull M; Division of Pediatric Hematology Oncology, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Jazyk: angličtina
Zdroj: Journal of paediatrics and child health [J Paediatr Child Health] 2022 Oct; Vol. 58 (10), pp. 1829-1835. Date of Electronic Publication: 2022 Jul 13.
DOI: 10.1111/jpc.16118
Abstrakt: Aim: Children with sickle cell disease (SCD) have historically weighed less than their healthy peers. More recently, a retrospective chart review from six institutions in New England reported nearly one-quarter of children and adolescents with SCD had raised body mass index (BMI). This study aimed to examine rates of children with SCD with raised BMI in Mississippi compared to state and national norms and assess the correlation between haemoglobin and BMI.
Methods: A retrospective chart review of paediatric patients with SCD at the University of Mississippi Medical Center (UMMC) was conducted using data from the most recent clinic visit. Mississippi and national weight status estimates for youth 10-17 years were obtained from the 2016-2017 National Survey of Children's Health.
Results: For youth 10-17 years with SCD (n = 345), 21.4.% of children with SS/Sβ° and 36.1% with SC/Sβ + had raised BMI compared to Mississippi and national rates, 39.2 and 31%, respectively. The prevalence of children with raised BMI with SC/Sβ + did not differ from state and national rates, while children with SS/Sβ° were half as likely as their Mississippi peers to have raised BMI. Haemoglobin levels were different among children with SCD who had low BMI (8.80 g/dL), average BMI (9.2 g/dL) and raised BMI (10.5 g/dL) (P < 0.001).
Conclusions: Children with SCD evaluated at UMMC have similar rates of raised BMI compared to state and national norms. Children with raised BMI have higher mean haemoglobin levels compared to children with SCD with low or average BMI.
Implications and Contribution: Historically, patients with SCD have been underweight and normal weight. Our paediatric and adolescent patients with SCD now have prevalence rates of raised BMI that approach state and national rates. Further work must be done to determine whether this reflects healthier children with SCD or raises concerns about life-style-related comorbidities.
(© 2022 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).)
Databáze: MEDLINE
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