Duplication of AKT2 Gene in Ovarian Cancer: A Potentially Novel Mechanism for Tumor-Induced Hypoglycemia.
| Autor: | Alkaissi HR; Internal Medicine, Kings County Hospital Center, Brooklyn, USA.; Internal Medicine, Veterans Affairs Medical Center, Brooklyn, USA.; Internal Medicine, State University of New York Downstate Medical Center, Brooklyn, USA., Mostel Z; Internal Medicine, State University of New York Downstate Medical Center, Brooklyn, USA.; Internal Medicine, Kings County Hospital Center, Brooklyn, USA.; Internal Medicine, Veterans Affairs Medical Center, Brooklyn, USA., McFarlane SI; Internal Medicine, Downstate-Health Science University, Brooklyn, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2022 Jun 10; Vol. 14 (6), pp. e25813. Date of Electronic Publication: 2022 Jun 10 (Print Publication: 2022). |
| DOI: | 10.7759/cureus.25813 |
| Abstrakt: | Severe hypoglycemia occurs with different types of tumors, including islet cell and non-islet cell tumors. Non-islet cell tumor hypoglycemia (NICTH) is a rare and potentially life-threatening complication of malignancy. The primary underlying mechanism of NICTH proposed in the literature includes paraneoplastic overproduction of insulin-like growth factor-2 (IGF-2), the production of autoantibodies against insulin or its receptors, or the presence of extensive metastatic burden replacing hepatic tissue or adrenal glands. In this report, we propose a potentially novel mechanism underlying NICTH involving stimulation of the insulin signaling pathway in a 58-year-old woman with a rare ovarian tumor of Müllerian origin that carries a duplication of the AKT2 gene. AKT2 is a molecular mediator of insulin signaling. To our knowledge, this is the first reported case of tumor-induced hypoglycemia associated with AKT2 gene duplication. In this report also, we discuss the currently available diagnostic modalities and highlight the therapeutic rationale in patients with NICTH, a highly vulnerable population. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Alkaissi et al.) |
| Databáze: | MEDLINE |
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