The Role of Preoperative Neutrophil, Platelet, and Monocyte to Lymphocyte Ratios as Independent Prognostic Factors for Patient Survival in WHO 2021 Glioblastoma: A Single-Center Retrospective Study.

Autor:	Stoyanov GS; General and Clinical Pathology/Forensic Medicine and Deontology, Medical University of Varna, Varna, BGR., Lyutfi E; Neurology and Neuroscience, Medical University of Varna, Varna, BGR., Georgieva R; Faculty of Medicine, Medical University of Varna, Varna, BGR., Dzhenkov DL; General and Clinical Pathology/Forensic Medicine and Deontology, Medical University of Varna, Varna, BGR., Petkova L; General and Clinical Pathology/Forensic Medicine and Deontology, Medical University of Varna, Varna, BGR., Ivanov BD; Clinical Medical Science, Medical University of Varna, Varna, BGR., Kaprelyan A; Neurology and Neuroscience, Medical University of Varna, Varna, BGR., Ghenev P; General and Clinical Pathology/Forensic Medicine and Deontology, Medical University of Varna, Varna, BGR.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Jun 09; Vol. 14 (6), pp. e25801. Date of Electronic Publication: 2022 Jun 09 (Print Publication: 2022).
DOI:	10.7759/cureus.25801
Abstrakt:	Introductions Immuno-oncology is a rapidly developing field wherein tumor-immune system interactions can be harnessed for diagnostics. Herein, we set out to establish the role of the immune system response, as measured by preoperative neutrophil, platelet, and monocyte to lymphocyte ratios (NLR, PLR, and MLR) as prognostic markers for patient survival based on the newly defined criteria for glioblastoma (GBM). Materials and methods The study included patients diagnosed with GBM at a four-year interval. Exclusion criteria were patients subject to reoperation in the time period; tumors in more than one system; a history of hematological and autoimmune diseases; and cases with infectious or other inflammatory conditions. Data regarding patient demographics and preoperative blood counts were pulled from patient records and compared to postoperative survival. Results A total of 22 patients fit the established criteria, with a male to female ratio of 2.14:1, a mean age of 66.23 years, and a mean survival of 255.72 days (8.04 months, range 24-801 days). Eight patients had an elevation of NLR and five of PLR, with no statistical correlation to survival. Six patients had an increase in MLR with a statistically significant (p=0.0044) shorter postoperative survival. Synergic increases in NLR and PLR did not show significance, while synergic increases with MLR showed no added benefit. Conclusion Preoperative MLR, but not NLR or PLR, is a promising independent biomarker for patient survival in GBM. It is suggested that elevations in these ratios directly correlate to tumor biological potential. Competing Interests: The study was funded by Medical University - Varna Scientific Fund, grant number 19010 and National scientific fund - young researchers (Republic of Bulgaria) grant number 2990/07.06.2021. The author would like to disclose, that one of the authors (George Stoyanov, MD, Ph.D.) as of the time of the submission of the manuscript is a member of the editorial approval board of the journal (Cureus). The authors affirm that this in no way, shape, or form resulted in manipulation of the reviewer selection process, reviews themselves, or the initial of the final editorial decision. (Copyright © 2022, Stoyanov et al.)
Databáze:	MEDLINE
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