Influence of Supraphysiologic Biomaterial Stiffness on Ventricular Mechanics and Myocardial Infarct Reinforcement.

Autor: Ghanta RK; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX United States; Department of Cardiovascular Surgery, Texas Heart Institute, Houston, TX United States. Electronic address: ghanta@bcm.edu., Pugazenthi A; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX United States., Zhao Y; Department of Surgery, University of Maryland, Baltimore, MD United States., Sylvester C; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX United States; Medical Scientist Training Program, Baylor College of Medicine, Houston, TX United States., Wall MJ Jr; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX United States., Mazur RA; Department of Chemical Engineering, University of Virginia, Charlottesville, VA United States., Russell LN; Department of Chemical Engineering, University of Virginia, Charlottesville, VA United States., Lampe KJ; Department of Chemical Engineering, University of Virginia, Charlottesville, VA United States.
Jazyk: angličtina
Zdroj: Acta biomaterialia [Acta Biomater] 2022 Sep 01; Vol. 149, pp. 30-39. Date of Electronic Publication: 2022 Jul 10.
DOI: 10.1016/j.actbio.2022.07.006
Abstrakt: Injectable intramyocardial biomaterials have promise to limit adverse ventricular remodeling through mechanical and biologic mechanisms. While some success has been observed by injecting materials to regenerate new tissue, optimal biomaterial stiffness to thicken and stiffen infarcted myocardium to limit adverse remodeling has not been determined. In this work, we present an in-vivo study of the impact of biomaterial stiffness over a wide range of stiffness moduli on ventricular mechanics. We utilized injectable methacrylated polyethylene glycol (PEG) hydrogels fabricated at 3 different mechanical moduli: 5 kPa (low), 25 kPa (medium/myocardium), and 250 kPa (high/supraphysiologic). We demonstrate that the supraphysiological high stiffness favorably alters post-infarct ventricular mechanics and prevents negative tissue remodeling. Lower stiffness materials do not alter mechanics and thus to be effective, must instead target biological reparative mechanisms. These results may influence rationale design criteria for biomaterials developed for infarct reinforcement therapy. STATEMENT OF SIGNIFICANCE: Acellular biomaterials for cardiac application can provide benefit via mechanical and biological mechanisms post myocardial infarction. We study the role of biomaterial mechanical characteristics on ventricular mechanics in myocardial infarcts. Previous studies have not measured the influence of injected biomaterials on ventricular mechanics, and consequently rational design criteria is unknown. By utilizing an in-vivo assessment of ventricular mechanics, we demonstrate that low stiffness biomaterial do not alter pathologic ventricular mechanics. Thus, to be effective, low stiffness biomaterials must target biological reparative mechanisms. Physiologic and supra-physiologic biomaterials favorably alter post-infarct mechanics and prevents adverse ventricular remodeling.
Competing Interests: Declaration of Competing Interest The authors report no conflict of interests.
(Copyright © 2022. Published by Elsevier Ltd.)
Databáze: MEDLINE
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