Incidence trends and survival analysis of atypical meningiomas: a population-based study from 2004 to 2018.

Autor: Recker MJ; Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, 100 High Street, Suite B4, Buffalo, NY, 14203, USA.; Department of Neurosurgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Kuo CC; Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, Buffalo, NY, USA., Prasad D; Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, 100 High Street, Suite B4, Buffalo, NY, 14203, USA.; Department of Neurosurgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.; Department of Radiation Oncology, Jacobs School of Medicine at the University at Buffalo, Buffalo, NY, USA.; Department of Radiation Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Attwood K; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA., Plunkett RJ; Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, 100 High Street, Suite B4, Buffalo, NY, 14203, USA. rplunkett@ubns.com.; Department of Neurosurgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. rplunkett@ubns.com.
Jazyk: angličtina
Zdroj: Journal of neuro-oncology [J Neurooncol] 2022 Oct; Vol. 160 (1), pp. 13-22. Date of Electronic Publication: 2022 Jul 11.
DOI: 10.1007/s11060-022-04085-6
Abstrakt: Purpose: Atypical meningiomas have histologic and clinical features that fall between those for benign and malignant meningiomas. The incidence of atypical meningiomas has not been well studied with respect to changes in the World Health Organization (WHO) classification scheme over time.
Methods: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database was queried to obtain data from 2004 to 2018 for patients with all meningiomas, including atypical. Age-adjusted incidence rates were generated and annual percent change (APC) in the incidence rates was calculated with joinpoint regression. Survival was analyzed using the Kaplan-Meier method and Cox proportional hazards models.
Results: A total of 4476 patients diagnosed with meningioma were identified from the SEER 18 registries. The incidence of atypical meningioma increased at an APC of 5.6% [95% confidence interval [CI], 3.4-7.8]; significantly faster than all meningiomas, which rose at an APC of 2.5% (95%CI 1.8-3.1;p = 0.008). For atypical meningiomas, the 1, 3, 5, and 10-year survival rates were 91.9%, 81.3%, 68.8%, and 34.3%, respectively. Male sex, older age (≥ 60 years), and large tumor size (> 5 cm) were independent risk factors for an unfavorable prognosis.
Conclusions: The incidence of atypical meningioma was observed to be increasing relative to all meningiomas. It is important to diligently monitor atypical meningioma incidence and mortality rates over time to see whether observed uptrends persist. Continued effort toward improving outcomes in patients with atypical meningiomas is warranted, especially in light of an apparent rise in incidence.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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