Differential spatial distribution of white matter lesions in Parkinson's and Alzheimer's diseases and cognitive sequelae.

Autor: Grey MT; Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.; First Department of Neurology, St. Anne's Hospital, School of Medicine, Masaryk University, Pekařská, 602 00, Brno, Czech Republic., Mitterová K; Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.; First Department of Neurology, St. Anne's Hospital, School of Medicine, Masaryk University, Pekařská, 602 00, Brno, Czech Republic., Gajdoš M; Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic., Uher R; Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic., Klobušiaková P; Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic., Rektorová I; Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.; First Department of Neurology, St. Anne's Hospital, School of Medicine, Masaryk University, Pekařská, 602 00, Brno, Czech Republic., Rektor I; Central European Institute of Technology (CEITEC), Brain and Mind Research Program, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic. ivan.rektor@fnusa.cz.; First Department of Neurology, St. Anne's Hospital, School of Medicine, Masaryk University, Pekařská, 602 00, Brno, Czech Republic. ivan.rektor@fnusa.cz.; Masaryk University, CEITEC Neuroscience Center and First Department of Neurology, St. Anne's University Hospital, Pekařská 53, 656 91, Brno, Czech Republic. ivan.rektor@fnusa.cz.
Jazyk: angličtina
Zdroj: Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2022 Aug; Vol. 129 (8), pp. 1023-1030. Date of Electronic Publication: 2022 Jul 11.
DOI: 10.1007/s00702-022-02519-z
Abstrakt: White Matter Lesions (WML) are a radiological finding common in aged subjects. We explored the impact of WML on underlying neurodegenerative processes. We focused on the impact of WML on two neurodegenerative diseases with different pathology. In this cross-sectional study of 137 subjects (78 female, 59 men, mean age 67.2; 43-87 years), we compared WML in healthy controls (HC; n = 55), patients with Alzheimer's disease and amnestic Mild Cognitive Impairment (aMCI), and Parkinson's disease patients with normal cognition and with MCI. Subjects with AD and aMCI were treated as one group (n = 40), subjects with PD and PDMCI were another group (n = 42). MRI T2_FLAIR sequences were analyzed. WML were divided into periventricular (pWML) or subcortical (sWML) depending on their distance from the ventricles. Subjects from the AD + aMCI group, had a significantly greater volume of WML than both HC and the PD + PDMCI group. The volume of WML was greater in the PD + PDMCI than in HC but the difference was not significant. In AD + aMCI subjects, sWML and not pWML were related to a decrease in global cognitive functioning despite greater volume of pWML. In PD + PDMCI, pWML correlate with decline in executive functions and working memory. In HC, pWML correlated with the multidomain decrease corresponding with the aging. This points to a difference between normal aging and pathological aging due to AD and PD brain pathology. The WML location together with underlying disease related neurodegeneration may play a role in determining the effect of WML on cognition. Our results suggest that the impact of WML is not uniform in all patients; rather, their volume, location and cognitive effect may be disease-specific.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Databáze: MEDLINE
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