Intratumoral Heterogeneity and Immune Modulation in Lung Adenocarcinoma in Female Smokers and Never Smokers.

Autor:	Trefzer TB; Charité - Universitätsmedizin Berlin and Berlin Institute of Health, Digital Health Center, Berlin, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Schneider MA; Translational Research Unit, Thoraxklinik, Heidelberg University Hospital, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Jechow K; Charité - Universitätsmedizin Berlin and Berlin Institute of Health, Digital Health Center, Berlin, Germany., Chua RL; Charité - Universitätsmedizin Berlin and Berlin Institute of Health, Digital Health Center, Berlin, Germany., Muley T; Translational Research Unit, Thoraxklinik, Heidelberg University Hospital, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Winter H; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.; Department of Surgery, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany., Kriegsmann M; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Meister M; Translational Research Unit, Thoraxklinik, Heidelberg University Hospital, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Eils R; Charité - Universitätsmedizin Berlin and Berlin Institute of Health, Digital Health Center, Berlin, Germany.; Health Data Science Unit, Heidelberg University Hospital and BioQuant, Heidelberg, Germany., Conrad C; Charité - Universitätsmedizin Berlin and Berlin Institute of Health, Digital Health Center, Berlin, Germany.
Jazyk:	angličtina
Zdroj:	Cancer research [Cancer Res] 2022 Sep 02; Vol. 82 (17), pp. 3116-3129.
DOI:	10.1158/0008-5472.CAN-21-3836
Abstrakt:	Significance: Single-cell analysis of healthy lung tissue and lung cancer reveals distinct tumor cell populations, including cells with differential immune modulating capacity between smokers and never smokers, which could guide future therapeutic strategies. (©2022 The Authors; Published by the American Association for Cancer Research.)
Databáze:	MEDLINE
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