Food-seeking behavior is triggered by skin ultraviolet exposure in males.

Autor: Parikh S; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Parikh R; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Michael K; Department of Human Services, The Max Stern Yezreel Valley Academic College, Yezreel Valley, Israel., Bikovski L; The Myers Neuro-Behavioral Core Facility, Tel Aviv University, Tel Aviv, Israel.; School of Behavioral Sciences, Netanya Academic College, Netanya, Israel., Barnabas G; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Mardamshina M; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Hemi R; Endocrine Service Unit, Sheba Medical Center Hospital, Tel Hashomer, Ramat Gan, Israel., Manich P; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Goldstein N; School of Public Health, Sackler Faculty of Medicine and Sylvan Adams Sports Institute, Tel Aviv University, Tel Aviv, Israel., Malcov-Brog H; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Ben-Dov T; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Otolaryngology, Head and Neck surgery, Meir Medical Center, Kfar Saba, Israel., Glaich O; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Liber D; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Bornstein Y; School of Public Health, Sackler Faculty of Medicine and Sylvan Adams Sports Institute, Tel Aviv University, Tel Aviv, Israel., Goltseker K; Zuckerman Mind Brain Behavior Institute, Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA., Ben-Bezalel R; School of Zoology, Faculty of Life Science, Tel Aviv University, Tel Aviv, Israel., Pavlovsky M; Division of Dermatology, Tel Aviv Sourasky (Ichilov) Medical Center, Tel Aviv, Israel., Golan T; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Spitzer L; Division of Dermatology, Tel Aviv Sourasky (Ichilov) Medical Center, Tel Aviv, Israel., Matz H; Division of Dermatology, Tel Aviv Sourasky (Ichilov) Medical Center, Tel Aviv, Israel.; Phototherapy Unit, Assuta Medical Center, Tel Aviv, Israel.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Gonen P; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Percik R; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.; Division of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel., Leibou L; Department of Plastic and Reconstructive Surgery, E. Wolfson Medical Center, Holon, Israel., Perluk T; Department of Plastic and Reconstructive Surgery, E. Wolfson Medical Center, Holon, Israel., Ast G; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Frand J; Department of Plastic and Reconstructive Surgery, E. Wolfson Medical Center, Holon, Israel., Brenner R; Institute of Oncology, E. Wolfson Medical Center, Holon, Israel., Ziv T; The Smoler Proteomics Center, Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion, Haifa, Israel., Khaled M; INSERM 1279, Gustave Roussy, Université Paris-Saclay, Villejuif, France., Ben-Eliyahu S; School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Barak S; School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Karnieli-Miller O; Department of Medical Education, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Levin E; School of Zoology, Faculty of Life Science, Tel Aviv University, Tel Aviv, Israel., Gepner Y; School of Public Health, Sackler Faculty of Medicine and Sylvan Adams Sports Institute, Tel Aviv University, Tel Aviv, Israel., Weiss R; Department of Pediatrics, Ruth Rappaport Children's Hospital, Rambam Medical Center and Technion School of Medicine, Haifa, Israel., Pfluger P; Research Unit Neurobiology of Diabetes, Institute for Diabetes and Obesity, Helmholtz Zentrum München, German Centre for Diabetes Research (DZD), Neuherberg, Germany., Weller A; Department of Psychology and the Gonda Brain Research Center, Bar-Ilan University, Ramat Gan, Israel., Levy C; Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. carmitlevy@post.tau.ac.il.
Jazyk: angličtina
Zdroj: Nature metabolism [Nat Metab] 2022 Jul; Vol. 4 (7), pp. 883-900. Date of Electronic Publication: 2022 Jul 11.
DOI: 10.1038/s42255-022-00587-9
Abstrakt: Sexual dimorphisms are responsible for profound metabolic differences in health and behavior. Whether males and females react differently to environmental cues, such as solar ultraviolet (UV) exposure, is unknown. Here we show that solar exposure induces food-seeking behavior, food intake, and food-seeking behavior and food intake in men, but not in women, through epidemiological evidence of approximately 3,000 individuals throughout the year. In mice, UVB exposure leads to increased food-seeking behavior, food intake and weight gain, with a sexual dimorphism towards males. In both mice and human males, increased appetite is correlated with elevated levels of circulating ghrelin. Specifically, UVB irradiation leads to p53 transcriptional activation of ghrelin in skin adipocytes, while a conditional p53-knockout in mice abolishes UVB-induced ghrelin expression and food-seeking behavior. In females, estrogen interferes with the p53-chromatin interaction on the ghrelin promoter, thus blocking ghrelin and food-seeking behavior in response to UVB exposure. These results identify the skin as a major mediator of energy homeostasis and may lead to therapeutic opportunities for sex-based treatments of endocrine-related diseases.
(© 2022. The Author(s).)
Databáze: MEDLINE
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