Multitier mechanics control stromal adaptations in the swelling lymph node.

Autor: Assen FP; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria. frank.assen@meduniwien.ac.at.; Department of Dermatology, Medical University Vienna, Vienna, Austria. frank.assen@meduniwien.ac.at., Abe J; Department of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland., Hons M; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria.; BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic., Hauschild R; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Shamipour S; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Kaufmann WA; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Costanzo T; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Krens G; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Brown M; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Ludewig B; Institute of Immunobiology, Kantonsspital St Gallen, St Gallen, Switzerland., Hippenmeyer S; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Heisenberg CP; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Weninger W; Department of Dermatology, Medical University Vienna, Vienna, Austria., Hannezo E; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria., Luther SA; Department of Immunobiology, University of Lausanne, Epalinges, Switzerland., Stein JV; Department of Oncology, Microbiology and Immunology, University of Fribourg, Fribourg, Switzerland., Sixt M; Institute of Science and Technology Austria (ISTA), Klosterneuburg, Austria. sixt@ist.ac.at.
Jazyk: angličtina
Zdroj: Nature immunology [Nat Immunol] 2022 Aug; Vol. 23 (8), pp. 1246-1255. Date of Electronic Publication: 2022 Jul 11.
DOI: 10.1038/s41590-022-01257-4
Abstrakt: Lymph nodes (LNs) comprise two main structural elements: fibroblastic reticular cells that form dedicated niches for immune cell interaction and capsular fibroblasts that build a shell around the organ. Immunological challenge causes LNs to increase more than tenfold in size within a few days. Here, we characterized the biomechanics of LN swelling on the cellular and organ scale. We identified lymphocyte trapping by influx and proliferation as drivers of an outward pressure force, causing fibroblastic reticular cells of the T-zone (TRCs) and their associated conduits to stretch. After an initial phase of relaxation, TRCs sensed the resulting strain through cell matrix adhesions, which coordinated local growth and remodeling of the stromal network. While the expanded TRC network readopted its typical configuration, a massive fibrotic reaction of the organ capsule set in and countered further organ expansion. Thus, different fibroblast populations mechanically control LN swelling in a multitier fashion.
(© 2022. The Author(s).)
Databáze: MEDLINE
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