Receptor control by membrane-tethered ubiquitin ligases in development and tissue homeostasis.
| Autor: | Lebensohn AM; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address: andres.lebensohn@nih.gov., Bazan JF; ħ bioconsulting llc, Stillwater, MN, United States. Electronic address: jfbazan@gmail.com., Rohatgi R; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, United States; Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States. Electronic address: rrohatgi@stanford.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Current topics in developmental biology [Curr Top Dev Biol] 2022; Vol. 150, pp. 25-89. Date of Electronic Publication: 2022 Jun 11. |
| DOI: | 10.1016/bs.ctdb.2022.03.003 |
| Abstrakt: | Paracrine cell-cell communication is central to all developmental processes, ranging from cell diversification to patterning and morphogenesis. Precise calibration of signaling strength is essential for the fidelity of tissue formation during embryogenesis and tissue maintenance in adults. Membrane-tethered ubiquitin ligases can control the sensitivity of target cells to secreted ligands by regulating the abundance of signaling receptors at the cell surface. We discuss two examples of this emerging concept in signaling: (1) the transmembrane ubiquitin ligases ZNRF3 and RNF43 that regulate WNT and bone morphogenetic protein receptor abundance in response to R-spondin ligands and (2) the membrane-recruited ubiquitin ligase MGRN1 that controls Hedgehog and melanocortin receptor abundance. We focus on the mechanistic logic of these systems, illustrated by structural and protein interaction models enabled by AlphaFold. We suggest that membrane-tethered ubiquitin ligases play a widespread role in remodeling the cell surface proteome to control responses to extracellular ligands in diverse biological processes. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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