Incidence and predictors of priapism events in sickle cell anemia: a diary-based analysis.

Autor:	Idris IM; Department of Haematology, Aminu Kano Teaching Hospital/Bayero University, Kano, Nigeria., Abba A; Department of Haematology, Aminu Kano Teaching Hospital/Bayero University, Kano, Nigeria., Galadanci JA; Department of Computer Science, Bayero University, Kano, Nigeria., Aji SA; Department of Surgery, Aminu Kano Teaching Hospital, Kano, Nigeria., Jibrilla AU; Department of Surgery, Aminu Kano Teaching Hospital, Kano, Nigeria., Rodeghier M; Mark Consulting, Chicago, IL., Kassim A; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Burnett AL; School of Medicine, Johns Hopkins University, Baltimore, MD., DeBaun MR; Vanderbilt-Meharry Sickle Cell Disease Center of Excellence, Vanderbilt University Medical Center, Nashville, TN.
Jazyk:	angličtina
Zdroj:	Blood advances [Blood Adv] 2022 Oct 25; Vol. 6 (20), pp. 5676-5683.
DOI:	10.1182/bloodadvances.2022007285
Abstrakt:	We conducted one of the first prospective studies to test the hypothesis that the clinical history of priapism underestimates priapism incidence compared with a priapism pain diary. Eligibility criteria were men with sickle cell anemia (SCA) between 18 and 40 years of age who have had at least 3 episodes of priapism in the past 12 months. Seventy-one men with SCA completed the diary for at least 3 months. The first 3 months of the priapism diary were included in the analysis. A total of 298 priapism episodes were recorded, and 80% (57 of 71) of the participants had at least 1 priapism event. Priapism severity was reported in the range of moderate to the worst imaginable pain in 81.5% (263 of 298), and a total 57 participants (80%) had a median pain rating of 6 (interquartile range: 5-8) on a scale from 1 to 10. The monthly incidence rate of priapism per participant based on history versus self-report pain diary was 2.0 (95% confidence interval, 1.9-2.1) and 1.4 (95% confidence interval, 1.2-1.6), respectively (P < .001). For participants that had a prior priapism episode, 80% had another episode during the 3-month interval follow-up. The median time to that second episode was 27.5 days. Major priapism occurred in 9.9% of episodes and was associated with the sum of all prospective priapism events. Men with SCA and at least 3 priapism episodes in the past 12 months are at significant risk for recurrent priapism in the following 3 months. (© 2022 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu