Serum ciliary neurotrophic factor levels in children with attention deficit hyperactivity disorder.

Autor: Buyuktaskin D; Department of Child and Adolescent Psychiatry, Gazi University Medical Faculty, Ankara, Turkey.; Department of Child and Adolescent Psychiatry, Cizre State Hospital, Sirnak, Turkey., Guney E; Department of Child and Adolescent Psychiatry, Gazi University Medical Faculty, Ankara, Turkey., Gulbahar O; Department of Medical Biochemistry, Gazi University Medical Faculty, Ankara, Turkey., Ozaslan A; Department of Child and Adolescent Psychiatry, Gazi University Medical Faculty, Ankara, Turkey., Arslan B; Department of Medical Biochemistry, Gazi University Medical Faculty, Ankara, Turkey.; Department of Medical Biochemistry, Erciş Şehit Rıdvan Çevik State Hospital, Van, Turkey.
Jazyk: angličtina
Zdroj: The International journal of neuroscience [Int J Neurosci] 2024 Apr; Vol. 134 (4), pp. 313-317. Date of Electronic Publication: 2022 Jul 19.
DOI: 10.1080/00207454.2022.2100782
Abstrakt: Purpose/aim of the study : The study aimed to highlight the possible role of ciliary neurotrophic factor (CNTF) in the pathophysiology of attention deficit hyperactivity disorder (ADHD) and determine whether CNTF can be used as a biomarker for ADHD. Materials and methods : Patients with a diagnosis of ADHD and neurotypical subjects aged 6-12 years were recruited prospectively. The study applied Conners' Teacher Rating Scale (CTRS) to determine the patients' ADHD predominance and severity. Serum CNTF levels were measured with an enzyme-linked immunosorbent assay (ELISA) kit. Results: A total of 43 ADHD patients and 33 healthy controls were included in the study. A significant difference was found between the serum CNTF levels of the ADHD patients (22.17 pg/ml) and the controls (22.80 pg/ml). Correlations between the CNTF levels and CTRS scores were not significant. Conclusions: The study identified an alteration of serum CNTF levels in ADHD patients and thus asserted a link between CNTF and ADHD pathophysiology; children with ADHD had significantly lower serum CNTF levels compared to the neurotypical controls. Further research is needed to understand the mechanisms of CNTF.
Databáze: MEDLINE
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