Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo .

Autor: Marques Meccatti V; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil., de Souza Moura L; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil., Guerra Pinto J; Photobiology Applied to Health (PHOTOBIOS)-University of Vale do Paraiba, Research and Development Institute. Av. Shishima Hifumi, 2911-São José dos Campos, São Paulo, Brazil., Ferreira-Strixino J; Photobiology Applied to Health (PHOTOBIOS)-University of Vale do Paraiba, Research and Development Institute. Av. Shishima Hifumi, 2911-São José dos Campos, São Paulo, Brazil., Abu Hasna A; Department of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil., Alves Figueiredo-Godoi LM; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil., Campos Junqueira J; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil., Marcucci MC; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil., de Paula Ramos L; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil., Carvalho CAT; Department of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil., Pucci CR; Department of Restorative Dentistry, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil., de Oliveira LD; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: International journal of dentistry [Int J Dent] 2022 Jul 01; Vol. 2022, pp. 5837864. Date of Electronic Publication: 2022 Jul 01 (Print Publication: 2022).
DOI: 10.1155/2022/5837864
Abstrakt: Radiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa) ; the antifungal activity of C. longa , curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes "LED" on Candida albicans and Candida tropicalis in vitro ; and the toxicity of C. longa and curcumin in Galleria mellonella model. In order to confirm the light absorption capacity of the C. longa extract, its phototransformation potential was evaluated. The antifungal effect of C. longa , curcumin, and aPDT was evaluated over Candida spp. Finally, the toxicity of C. longa and curcumin was evaluated on the Galleria mellonella model. The data were analyzed using the GraphPad Prism 5.0 software considering α  = 5%. It was found that C. longa , curcumin, and aPDT using blue LED have an antifungal effect over C. albicans and C. tropicalis . The extract of C. longa 100 mg/mL and curcumin 200  μ g/mL do not show toxicity on Galleria mellonella model.
Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this article.
(Copyright © 2022 Vanessa Marques Meccatti et al.)
Databáze: MEDLINE
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