Evaluation of nintedanib as a new postoperative antiscarring agent in experimental extraocular muscle surgery.

Autor:	Bicaklioglu G; Department of Ophthalmology, University of Health Sciences Trabzon Kanuni Training and Research Hospital, Trabzon 61250, Turkey., Pirhan D; Department of Ophthalmology, Kocaeli University, Faculty of Medicine, Kocaeli 41380, Turkey., Yazir Y; Stem Cell and Gene Therapy Research and Application Center, Kocaeli University, Kocaeli 41380, Turkey.; Department of Histology and Embryology, Kocaeli University, Faculty of Medicine, Kocaeli 41380, Turkey., Duruksu G; Stem Cell and Gene Therapy Research and Application Center, Kocaeli University, Kocaeli 41380, Turkey., Furat Rencber S; Department of Histology and Embryology, Kocaeli University, Faculty of Medicine, Kocaeli 41380, Turkey., Yuksel N; Department of Ophthalmology, Kocaeli University, Faculty of Medicine, Kocaeli 41380, Turkey.
Jazyk:	angličtina
Zdroj:	International journal of ophthalmology [Int J Ophthalmol] 2022 Jun 18; Vol. 15 (6), pp. 914-923. Date of Electronic Publication: 2022 Jun 18 (Print Publication: 2022).
DOI:	10.18240/ijo.2022.06.08
Abstrakt:	Aim: To investigate the efficacy of nintedanib on reducing postoperative inflammation, fibrosis and adhesion formation following extraocular muscle surgery in rabbits in comparison with triamcinolone acetonide (TA). Methods: Reinsertion of superior rectus muscle in right eyes of 30 New Zealand white rabbits were performed. They were randomized to receive one of the following treatments: 0.9% normal saline, one of 1-, 5-, and 10 µmol doses of nintedanib subconjunctivally immediately after surgery and on postoperative day 1, 2, 3, 5, and 7, and TA immediately after surgery. As a control group, unoperated left eyes ( n =6) were used. On the 28 th day, six eyes from each group were enucleated and histopathologically and immunohistochemically analyzed to assess the postoperative inflammatory changes, fibrosis and adhesion. Transforming growth factor beta, matrix metalloproteinase-2 and alpha smooth muscle actin expressions were evaluated. Results: Conjunctival and scleral inflammation in TA and nintedanib groups were significantly reduced compared to saline (sham) group. Conjunctival vascularity and rectus muscle fibrosis were significantly reduced in 10 µmol nintedanib group. Nintedanib groups were the most effective groups in reduction of perimuscular fibrosis. Neither three nintedanib groups nor TA group differed statistically from sham group with regard to adhesion. The expressions of transforming growth factor beta, alpha smooth muscle actin and matrix metalloproteinase-2 were reduced in nintedanib groups compared to saline group. Conclusion: Nintedanib appears to attenuate postoperative inflammation and fibrosis after extraocular muscle surgery. Nintedanib may be a safer and stronger alternative agent in extraocular muscle surgery when compared to steroids. Further investigation is needed to prove antiadhesive effect of nintedanib. (International Journal of Ophthalmology Press.)
Databáze:	MEDLINE
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