Vascular and microstructural markers of cognitive pathology.

Autor: Coffin C; Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston-Salem North Carolina USA., Suerken CK; Department of Biostatistics and Data Science Division of Public Health Sciences Wake Forest School of Medicine Winston-Salem North Carolina USA., Bateman JR; Department of Neurology Wake Forest School of Medicine Winston-Salem North Carolina USA., Whitlow CT; Department of Radiology Wake Forest School of Medicine Winston-Salem North Carolina USA., Williams BJ; Department of Neurology Wake Forest School of Medicine Winston-Salem North Carolina USA., Espeland MA; Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston-Salem North Carolina USA.; Department of Biostatistics and Data Science Division of Public Health Sciences Wake Forest School of Medicine Winston-Salem North Carolina USA., Sachs BC; Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston-Salem North Carolina USA.; Department of Neurology Wake Forest School of Medicine Winston-Salem North Carolina USA., Cleveland M; Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston-Salem North Carolina USA., Yang M; Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston-Salem North Carolina USA., Rogers S; Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston-Salem North Carolina USA., Hayden KM; Department of Social Sciences and Health Policy Division of Public Health Sciences Wake Forest School of Medicine Winston-Salem North Carolina USA., Baker LD; Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston-Salem North Carolina USA., Williamson J; Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston-Salem North Carolina USA., Craft S; Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston-Salem North Carolina USA., Hughes TM; Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston-Salem North Carolina USA., Lockhart SN; Department of Internal Medicine Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston-Salem North Carolina USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2022 Jul 06; Vol. 14 (1), pp. e12332. Date of Electronic Publication: 2022 Jul 06 (Print Publication: 2022).
DOI: 10.1002/dad2.12332
Abstrakt: Introduction: Arterial stiffness may play a role in the development of dementia through poorly understood effects on brain microstructural integrity and perfusion.
Methods: We examined markers of arterial stiffness (carotid-femoral pulse wave velocity [cfPWV]) and elevated systolic blood pressure (SBP) in relation to cognitive function and brain magnetic resonance imaging macrostructure (gray matter [GM] and white matter [WM] volumes), microstructure (diffusion based free water [FW] and fractional anisotropy [FA]), and cerebral blood flow (CBF) in WM and GM in models adjusted for age, race, sex, education, and apolipoprotein E ε4 status.
Results: Among 460 participants (70 ± 8 years; 44 dementia, 158 mild cognitive impairment, 258 normal cognition), higher cfPWV and SBP were independently associated with higher FW, higher WM hyperintensity volume, and worse cognition (global and executive function). Higher SBP alone was significantly associated with lower WM and GM CBF.
Discussion: Arterial stiffness is associated with impaired WM microstructure and global and executive cognitive function.
Competing Interests: Hughes reports funding for this work from NIH P30 AG072947 and additional funding for other NIH grants to the institution, including R01AG054069 and R01AG058969. Lockhart reports funding for this work from NIH P30 AG072947 and additional funding for other NIH grants to the institution. Williams reports funding for this work from NIH P30 AG072947 and additional funding for other NIH grants to the institution. Espeland reports funding for this work from NIH P30 AG072947 and additional funding for other NIH grants to the institution; payments to him from Boehringer‐Ingelheim; and support from the DSMB for Jackson Heart, Ironwood Pharmaceuticals, Kaiser Permanente, Washington Health Research Institute. Williamson reports funding for this work from NIH P30 AG072947, additional funding from other NIH grants, Biogen, the Centers for Disease Control, and PCORI all to the institution. Bateman reports funding for this work from NIH P30 AG072947, other NIH grants, and funding for the ASPECT 20‐AVP‐786‐306 to the institution. Whitlow reports funding for this work from NIH P30 AG072947 and additional funding for other NIH grants to the institution. Cleveland reports funding for this work from NIH P30 AG072947 and additional funding for other NIH grants to the institution. Rogers reports funding for this work from NIH P30 AG072947 and additional funding for other NIH grants to the institution. Baker reports funding for this work from NIH P30 AG072947 and additional funding for other NIH grants to the institution. Sachs reports funding for this work from NIH P30 AG072947 and additional funding for other NIH grants to the institution. Hayden reports funding for this work from NIH P30 AG072947 and additional funding for other NIH grants to the institution; payments to her from Fred Hutchinson Cancer Research Center, University of North Carolina at Chapel Hill, the Alzheimer's Association, and NIH CSR. Yang reports funding for this work from NIH P30 AG072947 and additional funding for other NIH grants to the institution. Craft reports funding for this work from NIH P30 AG072947, additional funding from other NIH grants, and reports disclosures for: vTv Therapeutics, T3D Therapeutics, Cyclerion Inc, and Cognito Inc.
(© 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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