Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition.

Autor:	Semenov O; Regulation of Gene Expression Laboratory, Institute of Cytology RAS, Saint-Petersburg, Russia., Daks A; Regulation of Gene Expression Laboratory, Institute of Cytology RAS, Saint-Petersburg, Russia., Fedorova O; Regulation of Gene Expression Laboratory, Institute of Cytology RAS, Saint-Petersburg, Russia., Shuvalov O; Regulation of Gene Expression Laboratory, Institute of Cytology RAS, Saint-Petersburg, Russia., Barlev NA; Regulation of Gene Expression Laboratory, Institute of Cytology RAS, Saint-Petersburg, Russia.; Laboratory of Intracellular Signalling, Moscow Institute of Physics and Technology, Dolgoprudny, Russia.; The Group of Targeted Delivery Mechanisms of Nanosystems, Institute of Biomedical Chemistry, Moscow, Russia.
Jazyk:	angličtina
Zdroj:	Frontiers in molecular biosciences [Front Mol Biosci] 2022 Jun 23; Vol. 9, pp. 928399. Date of Electronic Publication: 2022 Jun 23 (Print Publication: 2022).
DOI:	10.3389/fmolb.2022.928399
Abstrakt:	The central role of an aberrantly activated EMT program in defining the critical features of aggressive carcinomas is well documented and includes cell plasticity, metastatic dissemination, drug resistance, and cancer stem cell-like phenotypes. The p53 tumor suppressor is critical for leashing off all the features mentioned above. On the molecular level, the suppression of these effects is exerted by p53 via regulation of its target genes, whose products are involved in cell cycle, apoptosis, autophagy, DNA repair, and interactions with immune cells. Importantly, a set of specific mutations in the TP53 gene (named Gain-of-Function mutations) converts this tumor suppressor into an oncogene. In this review, we attempted to contrast different regulatory roles of wild-type and mutant p53 in the multi-faceted process of EMT. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Semenov, Daks, Fedorova, Shuvalov and Barlev.)
Databáze:	MEDLINE
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