Cardioprotective effects of sinomenine in myocardial ischemia/reperfusion injury in a rat model.

Autor:	Lu C; Department of Heart Center, Qingdao Fuwai Cardiovascular Hospital, No.201 Nanjing Road, Qingdao City, Shandong Province 266034, China., Guo X; Department of Heart Center, Qingdao Fuwai Cardiovascular Hospital, No.201 Nanjing Road, Qingdao City, Shandong Province 266034, China., He X; Department of Emergency, Qingdao Fuwai Cardiovascular Hospital, No.201 Nanjing Road, Qingdao City, Shandong Province 266034, China., Chang Y; Department of Heart Center, Qingdao Fuwai Cardiovascular Hospital, No.201 Nanjing Road, Qingdao City, Shandong Province 266034, China., Zheng F; Department of Heart Center, Qingdao Fuwai Cardiovascular Hospital, No.201 Nanjing Road, Qingdao City, Shandong Province 266034, China., Xu C; Department of Heart Center, Qingdao Fuwai Cardiovascular Hospital, No.201 Nanjing Road, Qingdao City, Shandong Province 266034, China., Zhang S; Department of Heart Center, Qingdao Fuwai Cardiovascular Hospital, No.201 Nanjing Road, Qingdao City, Shandong Province 266034, China., Zhou Y; Department of Heart Center, Qingdao Fuwai Cardiovascular Hospital, No.201 Nanjing Road, Qingdao City, Shandong Province 266034, China., Li J; Department of Cardiac Ultrasound, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao City, Shandong Province 266000, China.
Jazyk:	angličtina
Zdroj:	Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2022 Jun; Vol. 30 (6), pp. 669-678. Date of Electronic Publication: 2022 Apr 21.
DOI:	10.1016/j.jsps.2022.04.005
Abstrakt:	Background: Ischemia reperfusion (I/R) play an imperative role in the expansion of cardiovascular disease. Sinomenine (SM) has been exhibited to possess antioxidant, anticancer, anti-inflammatory, antiviral and anticarcinogenic properties. The aim of the study was scrutinized the cardioprotective effect of SM against I/R injury in rat. Methods: Rat were randomly divided into normal control (NC), I/R control and I/R + SM (5, 10 and 20 mg/kg), respectively. Ventricular arrhythmias, body weight and heart weight were estimated. Antioxidant, inflammatory cytokines, inflammatory mediators and plasmin system indicator were accessed. Results: Pre-treated SM group rats exhibited the reduction in the duration and incidence of ventricular fibrillation, ventricular ectopic beat (VEB) and ventricular tachycardia along with suppression of arrhythmia score during the ischemia (30 and 120 min). SM treated rats significantly (P < 0.001) altered the level of antioxidant parameters. SM treatment significantly (P < 0.001) repressed the level of creatine kinase MB (CK-MB), creatine kinase (CK) and troponin I (Tnl). SM treated rats significantly (P < 0.001) repressed the tissue factor (TF), thromboxane B2 (TXB2), plasminogen activator inhibitor 1 (PAI-1) and plasma fibrinogen (Fbg) and inflammatory cytokines and inflammatory mediators. Conclusion: Our result clearly indicated that SM plays anti-arrhythmia effect in I/R injury in the rats via alteration of oxidative stress and inflammatory reaction. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2022 The Author(s).)
Databáze:	MEDLINE
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