Testosterone treatment restores vestibular function by enhancing neuronal survival in an experimental closed-head repetitive mild traumatic brain injury model.

Autor: Foecking EM; Loyola University Chicago, Department of Otolaryngology, Burn Shock Trauma Research Institute, Loyola University Chicago, 2160 South 1st Avenue, Maywood, IL 60153, the United States of America; Burn Shock Trauma Research Institute, Loyola University Chicago, 2160 South 1st Avenue, Maywood, IL 60153, the United States of America; Edward Hines Jr. VA Hospital Research Service, Hines, IL 60141, the United States of America. Electronic address: efoecking@luc.edu., Segismundo AB; Loyola University of Chicago, Biomedical Graduate School, 2160 South 1st Avenue, Maywood, IL 60153, the United States of America. Electronic address: Arthur.Segismundo@gmail.com., Lotesto KM; Burn Shock Trauma Research Institute, Loyola University Chicago, 2160 South 1st Avenue, Maywood, IL 60153, the United States of America. Electronic address: klotesto@luc.edu., Westfall EJ; Loyola University Medical Center, Department of Otolaryngology, 2160 South 1st Avenue, Maywood, IL 60153, the United States of America. Electronic address: ejwestfa@gmail.com., Bolduan AJ; Loyola University Medical Center, Department of Otolaryngology, 2160 South 1st Avenue, Maywood, IL 60153, the United States of America. Electronic address: Alyssa.Bolduan@gmail.com., Peter TK; Loyola University Medical Center, Department of Otolaryngology, 2160 South 1st Avenue, Maywood, IL 60153, the United States of America. Electronic address: tpeter24@gmail.com., Wallace DG; Northern Illinois University, Department of Psychology, 1425 Lincoln Hwy, DeKalb, IL 60115, the United States of America. Electronic address: Dwallace@niu.edu., Kozlowski DA; DePaul University, Department of Biological Sciences and Neuroscience Program, 2325 N., Chicago, IL 60604, the United States of America. Electronic address: Dkozlows@depaul.edu., Stubbs EB Jr; Edward Hines Jr. VA Research Service, Hines, IL 60141, the United States of America; Loyola University Medical Center, Department of Otolaryngology, 2160 South 1st Avenue, Maywood, IL 60153, the United States of America. Electronic address: Evan.Stubbs@va.gov., Marzo SJ; Loyola University Medical Center, Department of Otolaryngology, 2160 South 1st Avenue, Maywood, IL 60153, the United States of America. Electronic address: smarzo@lumc.edu., Byram SC; Loyola University Medical Center, Department of Anesthesiology and Perioperative Medicine, 2160 South 1st Avenue, Maywood, IL 60153, the United States of America; Edward Hines Jr. VA Hospital Research Service, Hines, IL 60141, the United States of America. Electronic address: Susanna.Byram@lumc.edu.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2022 Sep 05; Vol. 433, pp. 113998. Date of Electronic Publication: 2022 Jul 07.
DOI: 10.1016/j.bbr.2022.113998
Abstrakt: Repetitive mild traumatic brain injury (rmTBI) results in a myriad of symptoms, including vestibular impairment. The mechanisms underlying vestibular dysfunction in rmTBI patients remain poorly understood. Concomitantly, acute hypogonadism occurs following TBI and can persist chronically in many patients. Using a repetitive mild closed-head animal model of TBI, the role of testosterone on vestibular function was tested. Male Long Evans Hooded rats were randomly divided into sham or rmTBI groups. Significant vestibular deficits were observed both acutely and chronically in the rmTBI groups. Systemic testosterone was administered after the development of chronic vestibular dysfunction. rmTBI animals given testosterone showed improved vestibular function that was sustained for 175 days post-rmTBI. Significant vestibular neuronal cell loss was, however, observed in the rmTBI animals compared to Sham animals at 175 days post-rmTBI and testosterone treatment significantly improved vestibular neuronal survival. Taken together, these data demonstrate a critical restorative role of testosterone in vestibular function following rmTBI. This study has important clinical implications because it identifies testosterone treatment as a viable therapeutic strategy for the long-term recovery of vestibular function following TBI.
(Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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