Mechanotransduction in Skin Inflammation.

Autor: Shutova MS; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.; Department of Dermatology, Geneva University Hospitals, 1211 Geneva, Switzerland., Boehncke WH; Department of Pathology and Immunology, University of Geneva, 1211 Geneva, Switzerland.; Department of Dermatology, Geneva University Hospitals, 1211 Geneva, Switzerland.
Jazyk: angličtina
Zdroj: Cells [Cells] 2022 Jun 25; Vol. 11 (13). Date of Electronic Publication: 2022 Jun 25.
DOI: 10.3390/cells11132026
Abstrakt: In the process of mechanotransduction, the cells in the body perceive and interpret mechanical stimuli to maintain tissue homeostasis and respond to the environmental changes. Increasing evidence points towards dysregulated mechanotransduction as a pathologically relevant factor in human diseases, including inflammatory conditions. Skin is the organ that constantly undergoes considerable mechanical stresses, and the ability of mechanical factors to provoke inflammatory processes in the skin has long been known, with the Koebner phenomenon being an example. However, the molecular mechanisms and key factors linking mechanotransduction and cutaneous inflammation remain understudied. In this review, we outline the key players in the tissue's mechanical homeostasis, the available data, and the gaps in our current understanding of their aberrant regulation in chronic cutaneous inflammation. We mainly focus on psoriasis as one of the most studied skin inflammatory diseases; we also discuss mechanotransduction in the context of skin fibrosis as a result of chronic inflammation. Even though the role of mechanotransduction in inflammation of the simple epithelia of internal organs is being actively studied, we conclude that the mechanoregulation in the stratified epidermis of the skin requires more attention in future translational research.
Databáze: MEDLINE
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