| Autor: |
Wang Y; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Liu APY; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China.; Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong, China., Lee TM; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China.; Laboratory of Neuropsychology and Human Neuroscience, Department of Psychology, The University of Hong Kong, Hong Kong, China., Wong WHS; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Fong DYT; School of Nursing, The University of Hong Kong, Hong Kong, China., Leung LK; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China., Shing MMK; Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong, China., Ku DT; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China., Chan GC; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China.; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China., Tso WW; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China.; Department of Paediatrics and Adolescent Medicine, Hong Kong Children's Hospital, Hong Kong, China.; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China. |
| Abstrakt: |
Purpose: The neurocognitive outcomes of pediatric brain tumor survivors have been extensively studied but the risk and predictors for neurobehavioral impairment are less clearly defined. We systematically analyzed the rates of emotional, psychosocial, and attention problems in pediatric brain tumor survivors. Methods: PubMed, Web of Science, Embase, Scopus, and Cochrane were searched for articles published between January 2012 to April 2022. Eligible studies reported neurobehavioral outcomes for PBTS aged 2 to <23 years with a brain tumor diagnosis before 18 years of age. A random-effect meta-analysis was performed in R. Results: The search yielded 1187 unique publications, of which 50 were included in the quantitative analysis. The estimated risk of having emotional, psychosocial, and attention problems were 15% (95%CI 10−20%), 12% (95%CI 9−16%), and 12% (95%CI 9−16%), respectively. PBTS were more likely to have emotional difficulties (Hedge’s g = 0.43 [95%CI 0.34−0.52]), psychosocial problems (Hedge’s g = 0.46 [95%CI 0.33−0.58]), and attention problems (Hedge’s g = 0.48 [95%CI 0.34−0.63]) compared to normal/healthy control subjects. There was no significant difference in the rates of neurobehavioral impairment between children with and without history of cranial radiotherapy. Conclusions: PBTS are at elevated risk of neurobehavioral impairment. Neurobehavioral monitoring should be considered as the standard of care for PBTS. |
