Tri-Compartmental Restriction Spectrum Imaging Breast Model Distinguishes Malignant Lesions from Benign Lesions and Healthy Tissue on Diffusion-Weighted Imaging.

Autor: Besser AH; Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA., Fang LK; Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA., Tong MW; Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA., Andreassen MMS; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Postboks 8905, 7491 Trondheim, Norway., Ojeda-Fournier H; Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA., Conlin CC; Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA., Loubrie S; Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA., Seibert TM; Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA.; Department of Radiation Medicine and Applied Sciences, University of California-San Diego, La Jolla, CA 92093, USA.; Department of Bioengineering, University of California-San Diego, La Jolla, CA 92093, USA., Hahn ME; Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA., Kuperman JM; Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA., Wallace AM; Department of Surgery, University of California-San Diego, La Jolla, CA 92093, USA., Dale AM; Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA.; Department of Neuroscience, University of California-San Diego, La Jolla, CA 92093, USA., Rodríguez-Soto AE; Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA., Rakow-Penner RA; Department of Radiology, University of California-San Diego, La Jolla, CA 92093, USA.; Department of Bioengineering, University of California-San Diego, La Jolla, CA 92093, USA.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2022 Jun 30; Vol. 14 (13). Date of Electronic Publication: 2022 Jun 30.
DOI: 10.3390/cancers14133200
Abstrakt: Diffusion-weighted MRI (DW-MRI) offers a potential adjunct to dynamic contrast-enhanced MRI to discriminate benign from malignant breast lesions by yielding quantitative information about tissue microstructure. Multi-component modeling of the DW-MRI signal over an extended b -value range (up to 3000 s/mm 2 ) theoretically isolates the slowly diffusing (restricted) water component in tissues. Previously, a three-component restriction spectrum imaging (RSI) model demonstrated the ability to distinguish malignant lesions from healthy breast tissue. We further evaluated the utility of this three-component model to differentiate malignant from benign lesions and healthy tissue in 12 patients with known malignancy and synchronous pathology-proven benign lesions. The signal contributions from three distinct diffusion compartments were measured to generate parametric maps corresponding to diffusivity on a voxel-wise basis. The three-component model discriminated malignant from benign and healthy tissue, particularly using the restricted diffusion C 1 compartment and product of the restricted and intermediate diffusion compartments ( C 1 and C 2 ). However, benign lesions and healthy tissue did not significantly differ in diffusion characteristics. Quantitative discrimination of these three tissue types (malignant, benign, and healthy) in non-pre-defined lesions may enhance the clinical utility of DW-MRI in reducing excessive biopsies and aiding in surveillance and surgical evaluation without repeated exposure to gadolinium contrast.
Databáze: MEDLINE
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