HIV and Global Cardiovascular Health.

Autor: Wagle A; Department of Medicine, Johns Hopkins Division of Cardiology, Baltimore, MD, USA., Goerlich E; Department of Medicine, Johns Hopkins Division of Cardiology, Baltimore, MD, USA., Post WS; Department of Medicine, Johns Hopkins Division of Cardiology, Baltimore, MD, USA.; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Woldu B; Department of Medicine, Johns Hopkins Division of Cardiology, Baltimore, MD, USA.; MedStar Heart and Vascular Institute, Baltimore, MD, USA.; Department of Medicine, Division of Cardiology, MedStar Georgetown University, Washington, DC, USA., Wu KC; Department of Medicine, Johns Hopkins Division of Cardiology, Baltimore, MD, USA.; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hays AG; Department of Medicine, Johns Hopkins Division of Cardiology, Baltimore, MD, USA. ahays2@jhmi.edu.; Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ahays2@jhmi.edu.
Jazyk: angličtina
Zdroj: Current cardiology reports [Curr Cardiol Rep] 2022 Sep; Vol. 24 (9), pp. 1149-1157. Date of Electronic Publication: 2022 Jul 08.
DOI: 10.1007/s11886-022-01741-1
Abstrakt: Purpose of Review: Because of effective combination antiretroviral therapy, people living with HIV (PLWH) are living longer but developing chronic age-related conditions including cardiovascular disease (CVD), the leading cause of death globally. This review aims to discuss the epidemiology, mechanisms, and clinical considerations of CVD in PLWH from a global perspective.
Recent Findings: PLWH are at greater risk for CVD at chronologically younger ages than those without HIV. Potential underlying mechanisms for CVD in PLWH include systemic inflammation, comorbidities, immune-mediated, or treatment-related mechanisms. There is also risk factor variation based on geographical location, including non-traditional CVD risk factors. CVD is prevalent in PLWH and increasing on a global scale. Further understanding the unique epidemiology, risk factors, and treatment of CVD in this population will improve the care of PLWH.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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