Anthropogenic Disturbance Impacts Gut Microbiome Homeostasis in a Malagasy Primate.

Autor:	Wasimuddin; Institute of Evolutionary Ecology and Conservation Genomics, University of Ulm, Ulm, Germany.; CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India., Malik H; Centre for One Health, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India., Ratovonamana YR; Institute of Zoology, Animal Ecology and Conservation, Universität Hamburg, Hamburg, Germany.; Département Biologie Animale, Faculté des Sciences, Université d' Antananarivo, Antananarivo, Madagascar., Rakotondranary SJ; Institute of Zoology, Animal Ecology and Conservation, Universität Hamburg, Hamburg, Germany.; Département Biologie Animale, Faculté des Sciences, Université d' Antananarivo, Antananarivo, Madagascar., Ganzhorn JU; Institute of Zoology, Animal Ecology and Conservation, Universität Hamburg, Hamburg, Germany., Sommer S; Institute of Evolutionary Ecology and Conservation Genomics, University of Ulm, Ulm, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in microbiology [Front Microbiol] 2022 Jun 21; Vol. 13, pp. 911275. Date of Electronic Publication: 2022 Jun 21 (Print Publication: 2022).
DOI:	10.3389/fmicb.2022.911275
Abstrakt:	Increasing anthropogenic disturbances in Madagascar are exerting constrains on endemic Malagasy lemurs and their habitats, with possible effects on their health and survival. An important component of health is the gut microbiome, which might be disrupted by various stressors associated with environmental change. We have studied the gut microbiome of gray-brown mouse lemurs ( Microcebus griseorufus ), one of the smallest Malagasy primates and an important model of the convergent evolution of diseases. We sampled two sites: one situated in a national park and the other consisting of a more disturbed site around human settlement. We found that more intense anthropogenic disturbances indeed disrupted the gut microbiome of this lemur species marked by a reduction in bacterial diversity and a shift in microbial community composition. Interestingly, we noted a decrease in beneficial bacteria (i.e., members of the Bacteroidaceae family) together with a slight increase in disease-associated bacteria (i.e., members of the Veillonellaceae family), and alterations in microbial metabolic functions. Because of the crucial services provided by the microbiome to pathogen resistance and host health, such negative alterations in the gut microbiome of mouse lemurs inhabiting anthropogenically disturbed habitats might render them susceptible to diseases and ultimately affecting their survival in the shrinking biodiversity seen in Madagascar. Gut microbiome analyses might thus serve as an early warning signal for pending threats to lemur populations. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Wasimuddin, Malik, Ratovonamana, Rakotondranary, Ganzhorn and Sommer.)
Databáze:	MEDLINE
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