Click gold quantum dots biosynthesis with conjugation of quercetin for adenocarcinoma exertion.

Autor:	Pansare AV; Composite Group, Mechanical Systems Engineering, Swiss Federal Laboratories for Materials Science and Technology-Empa 8600 Dübendorf Switzerland giovanni.terrasi@empa.ch amol.pansare@empa.ch.; Department of Chemistry, University of Mumbai Santacruz (E) Mumbai 400098 India vishwanathrpatil03@gmail.com., Pansare PV; Ramnarain Ruia Autonomous College, University of Mumbai Matunga (E) India kaminidonde@ruiacollege.edu., Shedge AA; Department of Chemistry, University of Mumbai Santacruz (E) Mumbai 400098 India vishwanathrpatil03@gmail.com., Pansare SV; Department of Chemistry, University of Mumbai Santacruz (E) Mumbai 400098 India vishwanathrpatil03@gmail.com., Patil VR; Department of Chemistry, University of Mumbai Santacruz (E) Mumbai 400098 India vishwanathrpatil03@gmail.com., Terrasi GP; Composite Group, Mechanical Systems Engineering, Swiss Federal Laboratories for Materials Science and Technology-Empa 8600 Dübendorf Switzerland giovanni.terrasi@empa.ch amol.pansare@empa.ch., Donde KJ; Ramnarain Ruia Autonomous College, University of Mumbai Matunga (E) India kaminidonde@ruiacollege.edu.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2022 Jun 23; Vol. 12 (29), pp. 18425-18430. Date of Electronic Publication: 2022 Jun 23 (Print Publication: 2022).
DOI:	10.1039/d2ra02529a
Abstrakt:	We developed a cost-effective and eco-friendly click biosynthesis of small molecule quercetin-gold quantum dots (QRT-AuQDs) involving quick conjugation using an ultrasonication method at ambient temperature by utilizing QRT and gold ions in the proportion of 0.1 : 1 (molar ratio). A comparatively very short amount of time (60 seconds) was required as compared to conventional procedures. The present biomimetics research relates to the isolation of bioactive QRT by the circularly spread silica gel layer technique (CSSGLT) and characterization (UV-Vis, FTIR, NMR and DSC analysis). Characterization of the synthesized QRT-AuQDs conjugated complex was carried out by UV-Vis, HR-TEM, DLS, zeta potential and X-ray diffraction. The main objective of the present work was to study the comparative anticancer activity of QRT and QRT-AuQDs on human lung cancer HOP-62 and leukemia K-562 cell lines. The results suggested that QRT-AuQDs showed potential for applications in anticancer treatment and were found to be a more cytotoxic agent in comparison to QRT, causing > 50% inhibition of cancer cells at the concentration < 10 -7 M. Hence, small molecule conjugated QRT-AuQDs can be used as a promising material for biomedical, bioengineering and anti-infectives applications. Competing Interests: The authors certify that there is no conflict of interest for our work. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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