Association Between Gut Regulatory Hormones and Post-operative Weight Loss Following Gastrectomy in Patients With Gastric Cancer.

Autor: Jung HK; Departments of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea., Tae CH; Departments of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea., Lee HA; Clinical Trial Center, Mokdong Hospital, Ewha Womans University, Seoul, Korea., Lee KE; Departments of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea., Moon CM; Departments of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea., Kim SE; Departments of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea., Seoh JY; Departments of Microbiology, College of Medicine, Ewha Womans University, Seoul, Korea., Lee JH; Departments of Surgery, College of Medicine, Ewha Womans University, Seoul, Korea.
Jazyk: angličtina
Zdroj: Journal of neurogastroenterology and motility [J Neurogastroenterol Motil] 2022 Jul 30; Vol. 28 (3), pp. 409-417.
DOI: 10.5056/jnm21145
Abstrakt: Background/aims: Post-operative weight loss in patients with gastric cancer lead to a poor quality of life and long-term survival. This study aims to evaluate the effects of gut regulatory hormones on post-operative weight loss in patients with subtotal gastrectomy for gastric cancer.
Methods: This prospective study was conducted for 12 months post-surgery in 14 controls and 13 gastrectomy patients who underwent subtotal gastrectomy for gastric cancer. Serum plasma ghrelin, glucagon-like peptide-1, gastric inhibitory peptide-1, peptide YY, insulin, and homeostatic model assessment for insulin resistance responses to a standardized test meal were recorded at multiple time points before and after gastrectomy at 4 and 12 months.
Results: The mean weight difference between the pre-operative state and the 4-month period was significantly reduced to 6.6 kg ( P = 0.032), but significant weight reduction was not observed from 4 months to 12 months. The plasma levels of glucagon-like peptide-1, gastric inhibitory peptide-1, and peptide YY were significantly increased 4 months postoperatively compared to the pre-operative state (all P = 0.035); however, pre-operative levels and relative changes over a period of 0-4 months of hormones were not correlated with body weight changes. Only the pre-operative ghrelin at peak had a negative correlation with changes in weight reduction in the 4 months after surgery ( ρ = -0.8, P = 0.024).
Conclusions: Significant weight reduction was common after subtotal gastrectomy for gastric cancer with a negative correlation pre-operative plasma ghrelin levels. Incretin hormones are modestly but significantly increased after subtotal gastrectomy; however, these changes did not affect the weight changes.
Databáze: MEDLINE
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