Non-invasive follicular neoplasm with papillary-like nuclear features: a challenging and infrequent entity in Argentina.

Autor: Sabán M; Hospital Británico, Buenos Aires, Argentina. sabanmelina@gmail.com., Tolaba N; Hospital A. Oñativia, Salta, Argentina., Orlandi AM; Hospital T. Alvarez, Buenos Aires, Argentina., Deutsch S; Hospital 'J.A. Fernández', Buenos Aires, Argentina., Pitoia F; Hospital de Clínicas 'José de San Martín', Buenos Aires, Argentina., Lowenstein A; Hospital JM Ramos Mejía, Buenos Aires, Argentina., Calabrese MC; Hospital C. Durand, Buenos Aires, Argentina., Cavallo A; Hospital Alta Complejidad, Formosa, Argentina., Iotti A; Hospital Británico, Buenos Aires, Argentina., Monteros Alvi M; Hospital A. Oñativia, Salta, Argentina., Nallar M; Hospital A. Oñativia, Salta, Argentina., Jaén A; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Figurelli S; Hospital 'J.A. Fernández', Buenos Aires, Argentina., Carrizo F; Instituto de Oncología Ángel H. Roffo, Buenos Aires, Argentina., Colobraro A; Hospital JM Ramos Mejía, Buenos Aires, Argentina., García Tascón G; Hospital T. Alvarez, Buenos Aires, Argentina., Saccoliti M; Hospital C. Durand, Buenos Aires, Argentina., Paes de Lima A; Hospital de Clínicas 'José de San Martín', Buenos Aires, Argentina., Lencioni M; Hospital Alta Complejidad, Formosa, Argentina., Califano I; Instituto de Oncología Ángel H. Roffo, Buenos Aires, Argentina., Cabezón C; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: Endocrine [Endocrine] 2022 Sep; Vol. 77 (3), pp. 493-499. Date of Electronic Publication: 2022 Jul 07.
DOI: 10.1007/s12020-022-03115-7
Abstrakt: Purpose: Non-invasive encapsulated follicular variant of papillary thyroid cancer was reclassified as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). These neoplasms have an extremely low malignant potential. The aim of this study was (1) to assess the prevalence of NIFTP in patients with papillary thyroid carcinoma, (2) to evaluate their outcomes, and (3) to determine their molecular profile.
Methods: Multicenter, descriptive, retrospective study. Patients with papillary thyroid cancer diagnosed from January 2006 to December 2016 from 11 referral centers were included. Diagnosis of NIFTP was based on criteria described by Nikiforov et al. in 2018. At least two pathologists agreed on the diagnosis. Two thousand six hundred and seventy-seven papillary thyroid cancer patients were included; 456 (17%) of them were follicular variant papillary thyroid cancer, and 30 (1.12%) fulfilled diagnostic criteria for NIFTP.
Results: Each of the 30 included patients underwent a total thyroidectomy, and 50% were treated with radioiodine (median dose 100 mCi). After a median follow-up of 37 months, 84% of patients had an excellent response, 3% had an indeterminate response and data was missing in the remaining 13%. No metastatic lymph nodes, distant metastases or recurrences were found. RAS mutations were detected in 4 patients (13%).
Conclusion: The prevalence of NIFTP in our series is amongst the lowest reported. Excellent outcomes of patients underscore their low malignant potential. Molecular findings differ from other series, probably related to environmental or ethnic features of our population and the meticulous criteria for diagnosing NIFTP.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: