Sex-specific cardiometabolic risk markers of left ventricular mass in physically active young adults: the CHIEF heart study.

Autor: Tsai KZ; Department of Internal Medicine, Hualien Armed Forces General Hospital, No. 100, Jinfeng St., Hualien City, 970, Taiwan.; Department of Stomatology of Periodontology, Mackay Memorial Hospital, Taipei, Taiwan., Liu PY; Department of Internal Medicine, Hualien Armed Forces General Hospital, No. 100, Jinfeng St., Hualien City, 970, Taiwan.; Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan., Huang WC; College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Department of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan., Lima JAC; Departments of Cardiology and Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Lavie CJ; Ochsner Clinical School, John Ochsner Heart and Vascular Institute, The University of Queensland School of Medicine, New Orleans, LA, USA., Lin GM; Department of Internal Medicine, Hualien Armed Forces General Hospital, No. 100, Jinfeng St., Hualien City, 970, Taiwan. farmer507@yahoo.com.tw.; Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. farmer507@yahoo.com.tw.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jul 07; Vol. 12 (1), pp. 11536. Date of Electronic Publication: 2022 Jul 07.
DOI: 10.1038/s41598-022-15818-y
Abstrakt: Greater physical fitness may lead to greater left ventricular mass (LVM) and reduce the effect of cardiometabolic risk factors on LVM. However, the cardiometabolic biomarkers associations for LVM have not been clarified in physically active young adults. This study included 2019 men and 253 women, aged 18-43 years, from the military in Taiwan. All participants underwent anthropometric and blood metabolic markers measurements, and completed a 3000-m run test for assessing fitness. LVM was calculated on the basis of an echocardiography. Multiple linear regression was used to determine the sex-specific associations between cardiometabolic risk markers and LVM indexed for the body height (g/m 2.7 ). In men, age, systolic blood pressure (SBP), 3000-m running time, serum triglycerides, serum uric acid and waist circumference (WC) were correlated with LVM index (β = 0.07, 0.10, - 0.01, 0.01, 0.24 and 0.24, respectively; all p-values < 0.05). The correlations were not significant for fasting plasma glucose, total cholesterol and high-density lipoprotein cholesterol (HDL-C). In women, SBP, HDL-C and WC were correlated with LVM index in the univariate analysis (β = 0.07, - 0.05 and 0.32, respectively; all p-values < 0.05), whereas the correlation was only significant for WC in the multiple linear regression analysis (β = 0.20; p-value < 0.001). In physically active adults, the associations of cardiometabolic risk markers with LVM might vary by sex. Better endurance exercise performance associated with greater LVM was noted only in men, while greater WC was the only metabolic risk marker for greater LVM in both men and women.
(© 2022. The Author(s).)
Databáze: MEDLINE
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