Soft tissue sarcoma incidences and clinical characteristics are significantly different in France and Taiwan.

Autor: Chen TW; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan., Chiang RC; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.; Taiwan Cancer Registry, Taipei, Taiwan., Le Cesne A; Medical Oncology, Gustave Roussy Institute-Cancer Campus, Villejuif, France., Hsieh YC; Health Data Research Center, National Taiwan University, Taipei, Taiwan., Italiano A; Early Phase Trials Unit, Bergonie Institute, Bordeaux, France., Yang YW; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.; Taiwan Cancer Registry, Taipei, Taiwan., Penel N; General Oncology Department, Oscar Lambret Center, Lille, France., Lee WC; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.; Taiwan Cancer Registry, Taipei, Taiwan., Bompas E; Western Oncology Institute, Nantes, France., Valentin T; Claudius Regaud Institute, Toulouse, France., Anract P; Department of Orthopedics, Assistance publique Hopitaux de Paris, Paris, France., Firmin N; Montpellier Cancer Institute, Montpellier, France., Duffaud F; Medical Oncology, Greater Paris University Hospitals, Marseilles, France., Cheng AL; Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan., Ducimetiere F; Medicine Department, Leon Berard Center, Lyon, France., Chan KA; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan., Blay JY; Medicine Department, Leon Berard Center, Lyon, France.
Jazyk: angličtina
Zdroj: Cancer [Cancer] 2022 Sep 15; Vol. 128 (18), pp. 3360-3369. Date of Electronic Publication: 2022 Jul 07.
DOI: 10.1002/cncr.34372
Abstrakt: Background: The incidence of different soft tissue sarcoma (STS) histotypes among ethnic and geographic populations has not been comprehensively investigated.
Methods: Data from 2013 to 2016 were obtained from national cancer registry databases in France and Taiwan. Liposarcoma (LPS), leiomyosarcoma (LMS), angiosarcoma (AS), synovial sarcoma (SS), and malignant peripheral nerve sheath tumor (MPNST) were selected as index STSs to estimate the age-standardized incidence rates (ASRs) and other clinical features between patients.
Results: In total, 9398 patients (7148 from France and 2250 from Taiwan) were included. The ASRs of AS (5.4 vs. 2.8) and MPNST (2.0 vs. 1.0) were significantly higher in Taiwan; France had significantly higher ASRs for LPS (12.0 vs. 10.0), LMS (9.7 vs. 7.6), and SS (1.7 vs. 1.2). Patients in Taiwan with LMS or LPS were younger than their French counterparts. With regard to the distribution according to primary anatomic site, French patients had higher odds for extremity and truncal LMS (odds ratio [OR], 2.84; p < .001), AS (OR, 2.67; p < .001), MPNST (OR, 1.55; p = .027), and LPS (OR, 1.38; p < .001) and for breast AS (OR, 10.58; p < .001). Taiwanese patients had higher odds for liver AS (OR, 10.72; p < .001) and uterine LMS (OR, 3.21; p < .001). SS age and distribution according to primary anatomic site did not differ significantly between the French and Taiwanese populations.
Conclusions: Significant differences in the incidence and clinical characteristics of index STS suggested that geographic (environmental) and ethnicity factors likely play a vital role in the pathogenesis of STS.
(© 2022 American Cancer Society.)
Databáze: MEDLINE
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