Association of Plasma Neurofilament Light Chain With Glycaemic Control and Insulin Resistance in Middle-Aged Adults.

Autor:	Thota RN; Macquarie Medical School, Macquarie University, North Ryde, NSW, Australia.; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia., Chatterjee P; Macquarie Medical School, Macquarie University, North Ryde, NSW, Australia.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia., Pedrini S; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia., Hone E; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia., Ferguson JJA; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia., Garg ML; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia., Martins RN; Macquarie Medical School, Macquarie University, North Ryde, NSW, Australia.; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.; Australian Alzheimer's Research Foundation, Nedlands, WA, Australia.; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia.; The KaRa Institute of Neurological Disease, Macquarie Park, NSW, Australia.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Jun 20; Vol. 13, pp. 915449. Date of Electronic Publication: 2022 Jun 20 (Print Publication: 2022).
DOI:	10.3389/fendo.2022.915449
Abstrakt:	Aims: This study aimed to determine the association of plasma neurofilament light (NfL), a marker of neurodegeneration, with diabetes status and glycaemic parameters in people with normal glycaemia (NG), pre-diabetes (PD) and type 2 diabetes (T2D). Methods: Clinical and descriptive data for the diagnostic groups, NG (n=30), PD (n=48) and T2D (n=29), aged between 40 and 75 years were included in this cross-sectional analysis. Plasma NfL levels were analyzed using the ultra-sensitive single-molecule array (Simoa) platform. Results: A positive correlation was evident between plasma NfL and fasting glucose (r = 0.2824; p = 0.0032). Plasma NfL levels were not correlated with fasting insulin and insulin resistance. Plasma Nfl levels were significantly different across the diabetes groups (T2D >PD >NG, p=0.0046). Post-hoc analysis indicated significantly higher plasma NfL levels in the T2D [12.4 (5.21) pg/mL] group than in the PD [10.2 (4.13) pg/mL] and NG [8.37 (5.65) pg/mL] groups. The relationship between diabetes status and NfL remained significant after adjusting for age, sex, BMI, HOMA-IR and physical activity (adjusted r 2 = 0.271, p = 0.035). Conclusions: These results show biomarker evidence of neurodegeneration in adults at risk or with T2D. Larger sample size and longitudinal analysis are required to better understand the application of NfL in people with risk and overt T2D. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Thota, Chatterjee, Pedrini, Hone, Ferguson, Garg and Martins.)
Databáze:	MEDLINE
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