Genome-wide comparison deciphers lifestyle adaptation and glass biodeterioration property of Curvularia eragrostidis C52.

Autor: Quach NT; Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi, 100000, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, 10000, Vietnam., Ngo CC; Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi, 100000, Vietnam.; Vietnam-Russia Tropical Centre, Hanoi, 100000, Vietnam., Nguyen TH; Vietnam-Russia Tropical Centre, Hanoi, 100000, Vietnam., Nguyen PL; Vietnam-Russia Tropical Centre, Hanoi, 100000, Vietnam., Vu THN; Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi, 100000, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, 10000, Vietnam., Phan THT; Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, Nha Trang, 650000, Vietnam., Nguyen QH; LMI DRISA, Department of Life Sciences, University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, Hanoi, 100000, Vietnam., Le TTM; Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi, 100000, Vietnam., Chu HH; Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi, 100000, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, 10000, Vietnam., Phi QT; Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi, 100000, Vietnam. tienpq@ibt.ac.vn.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, 10000, Vietnam. tienpq@ibt.ac.vn.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jul 06; Vol. 12 (1), pp. 11411. Date of Electronic Publication: 2022 Jul 06.
DOI: 10.1038/s41598-022-15334-z
Abstrakt: Glass biodeterioration by fungi has caused irreversible damage to valuable glass materials such as cultural heritages and optical devices. To date, knowledge about metabolic potential and genomic profile of biodeteriorative fungi is still scarce. Here, we report for the first time the whole genome sequence of Curvularia eragrostidis C52 that strongly degraded silica-based glasses coated with fluorine and hafnium, as expressed by the hyphal surface coverage of 46.16 ± 3.3% and reduced light transmission of 50.93 ± 1.45%. The genome of C. eragrostidis C52 is 36.9 Mb long with a GC content of 52.1% and contains 14,913 protein-coding genes, which is the largest genome ever recorded in the genus Curvularia. Phylogenomic analysis revealed C. eragrostidis C52 formed a distinct cluster with Curvularia sp. IFB-Z10 and was not evolved from compared genomes. Genome-wide comparison showed that strain C52 harbored significantly higher proportion of proteins involved in carbohydrate-active enzymes, peptidases, secreted proteins, and transcriptional factors, which may be potentially attributed to a lifestyle adaptation. Furthermore, 72 genes involved in the biosynthesis of 6 different organic acids were identified and expected to be crucial for the fungal survival in the glass environment. To form biofilm against stress, the fungal strain utilized 32 genes responsible for exopolysaccharide production. These findings will foster a better understanding of the biology of C. eragrostidis and the mechanisms behind fungal biodeterioration in the future.
(© 2022. The Author(s).)
Databáze: MEDLINE
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