| Autor: |
Babu SS; Department of Chemistry, Indian Institute of Science Education and Research (IISER) Tirupati, Tirupati 517507, India., Gopinath P; Department of Chemistry, Indian Institute of Science Education and Research (IISER) Tirupati, Tirupati 517507, India. |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of organic chemistry [J Org Chem] 2022 Jul 15; Vol. 87 (14), pp. 9414-9418. Date of Electronic Publication: 2022 Jul 06. |
| DOI: |
10.1021/acs.joc.2c00832 |
| Abstrakt: |
Photoredox-mediated tandem addition-chemoselective cyclization of o -alkenyl aryl ureas is reported for the synthesis of sulfonyl and activated alkyl-decorated dihydroquinazolinones. By a careful choice of o -alkenyl aryl urea starting materials, we achieved chemoselective N-cyclization in the presence of more reactive amidic oxygen. We have demonstrated the scope of the methodology with a variety of sulfonyl chlorides and activated alkyl halides. Finally, large-scale synthesis of sulfonyl-substituted dihydroquinazolinone showcases the synthetic utility of the methodology. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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