Vitamin D and SARS-CoV2 infection, severity and mortality: A systematic review and meta-analysis.
Autor: | D'Ecclesiis O; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy., Gavioli C; Division of Epidemiology and Biostatistics, IEO European Institute of Oncology IRCCS, Milan, Italy., Martinoli C; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy., Raimondi S; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy., Chiocca S; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy., Miccolo C; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy., Bossi P; Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University of Brescia, ASST-Spedali Civili, Brescia, Italy., Cortinovis D; SC Oncologia Medica, Asst H S Gerardo Monza, Monza, Italy., Chiaradonna F; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy., Palorini R; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy., Faciotti F; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy., Bellerba F; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy., Canova S; SC Oncologia Medica, Asst H S Gerardo Monza, Monza, Italy., Jemos C; Department of Clinical Pharmacy, IEO, European Institute of Oncology IRCCS, Milan, Italy., Salé EO; Department of Clinical Pharmacy, IEO, European Institute of Oncology IRCCS, Milan, Italy., Gaeta A; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy., Zerbato B; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy., Gnagnarella P; Division of Epidemiology and Biostatistics, IEO European Institute of Oncology IRCCS, Milan, Italy., Gandini S; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy. |
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Jazyk: | angličtina |
Zdroj: | PloS one [PLoS One] 2022 Jul 06; Vol. 17 (7), pp. e0268396. Date of Electronic Publication: 2022 Jul 06 (Print Publication: 2022). |
DOI: | 10.1371/journal.pone.0268396 |
Abstrakt: | To assess the evidence on SARS-CoV2 infection and Covid-19 in relation to deficiency and supplementation of vitamin D, we conducted a systematic review up to April 2021. We summarised data from 38 eligible studies, which presented risk estimates for at least one endpoint, including two RCT and 27 cohort-studies: 205565 patients with information on 25OHD status and 2022 taking vitamin D supplementation with a total of 1197 admitted to the ICU or who needed invasive mechanical ventilation or intubation and hospital stay, and more than 910 Covid-19 deaths. Primary outcomes were severity and mortality and the main aim was to evaluate the association with vitamin D supplementation. Random effects models showed that supplementation was associated with a significant lower risk of both Covid-19 severe disease (SRR 0.38, 95% CI 0.20-0.72, 6 studies) and mortality (SRR 0.35, 95% CI 0.17-0.70, 8 studies). There were no statistically significant dose differences between studies: summary estimates with regular doses remain statistically significant, suggesting that higher doses are not necessary. For patients on vitamin D supplementation, a greater reduction in mortality risk emerged in older individuals and at higher latitudes. Regarding the quality of studies, assessed using the New Castle-Ottawa quality scale, the analysis revealed in most cases no statistically significant differences between low, medium or high quality studies. We found significant associations of vitamin D supplementation with Covid-19, encompassing risks of disease worsening and mortality, especially in seasons characterized by 25OHD deficiency and with not severe patients. Dedicated randomized clinical studies are encouraged to confirm these results. Competing Interests: The authors have declared that no competing interests exist. |
Databáze: | MEDLINE |
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