Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy.

Autor:	Al'Aref SJ; Department of Medicine, Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Altibi AM; Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA., Malkawi A; Department of Medicine, Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Mansour M; Department of Medicine, Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Baskaran L; Department of Cardiovascular Medicine, National Heart Centre, Singapore, Singapore., Masri A; Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA., Rahmouni H; Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA., Abete R; Department of Cardiology, Policlinico di Monza, Monza, Italy., Andreini D; Centro Cardiologico Monzino IRCCS, University of Milan, Milan, Italy., Aquaro G; U.O.C. Risonanza Magnetica per Immagini, Fondazione G. Monasterio CNR-Regione Toscana Pisa, Pisa, Italy., Barison A; U.O.C. Risonanza Magnetica per Immagini, Fondazione G. Monasterio CNR-Regione Toscana Pisa, Pisa, Italy., Bogaert J; Department of Radiology, University Hospital Leuven, Leuven, Belgium., Camastra G; Cardiac Department, Vannini Hospital Rome, Rome, Italy., Carigi S; Department of Cardiology, Infermi Hospital, Rimini, Italy., Carrabba N; Cardiovascular and Thoracic Department of Careggi Hospital, Florence, Italy., Casavecchia G; Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy., Censi S; Maria Cecilia Hospital, GVM Care & Research, Cotignola, RA, Italy., Cicala G; Radiology Department, Parma University Hospital, Via Gramsci, Parma, Italy., Conte E; Centro Cardiologico Monzino IRCCS, University of Milan, Milan, Italy., De Cecco CN; Division of Cardiothoracic Imaging, Emory University, Atlanta, GA, USA., De Lazzari M; Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Medical School, Padova, Italy., Di Giovine G; Department of Cardiology, Policlinico di Monza, Monza, Italy., Di Roma M; Radiology Department, Policlinico Casilino, Rome, Italy., Dobrovie M; Department of Radiology, University Hospital Leuven, Leuven, Belgium., Focardi M; Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy., Gaibazzi N; Department of Cardiology, Azienda Ospedaliero-Universitaria, Parma, Italy., Gismondi A; Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy., Gravina M; Department of Radiology, University of Foggia, Foggia, Italy., Guglielmo M; Centro Cardiologico Monzino IRCCS, University of Milan, Milan, Italy., Lanzillo C; Cardiology Department, Policlinico Casilino, Rome, Italy., Lombardi M; Multimodality Cardiac Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy., Lorenzoni V; Institute of Management, Scuola Superiore Sant'Anna, Pisa, Italy., Lozano-Torres J; Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Universitat Auto`noma de Barcelona, Barcelona, Spain., Margonato D; Department of Cardiology, Policlinico di Monza, Monza, Italy., Martini C; Scienze Radiologiche, Department of Medicine and Surgery, University of Parma, Parma, Italy., Marzo F; Department of Cardiology, Infermi Hospital, Rimini, Italy., Masci P; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK., Masi A; De Gasperis' Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., Memeo R; Institute of Cardiovascular Disease, Department of Emergency and Organ Transplantation, University Hospital Policlinico of Bari, Bari, Italy., Moro C; Department of Cardiology, ASST Monza, P.O. Desio, Italy., Mushtaq S; Centro Cardiologico Monzino IRCCS, University of Milan, Milan, Italy., Nese A; Dipartimento Neuro-Cardiovascolare, Ospedale Ca' Foncello Treviso, Treviso, Italy., Palumbo A; Cardiovascular Department, CMR Center, University Hospital Lausanne, CHUV, Lausanne, Switzerland., Pavon AG; Department of Radiology, Careggi Hospital, Florence, Italy., Pedrotti P; De Gasperis' Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., Pepi M; Centro Cardiologico Monzino IRCCS, University of Milan, Milan, Italy., Perazzolo Marra M; Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Medical School, Padova, Italy., Pica S; Multimodality Cardiac Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy., Pradella S; Division of Cardiology, Loyola University of Chicago, Chicago, IL, USA., Presicci C; Scienze Radiologiche, Department of Medicine and Surgery, University of Parma, Parma, Italy., Rabbat MG; Division of Cardiology, Loyola University of Chicago, Chicago, IL, USA., Raineri C; Department of Cardiology, Citta` della salute e della Scienza - Ospedale Molinette, Turin, Italy., Rodriguez-Palomares JF; Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Universitat Auto`noma de Barcelona, Barcelona, Spain., Sbarbati S; Radiology Department, Vannini Hospital Rome, Rome, Italy., Schoepf UJ; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA., Squeri A; Maria Cecilia Hospital, GVM Care & Research, Cotignola, RA, Italy., Sverzellati N; Scienze Radiologiche, Department of Medicine and Surgery, University of Parma, Parma, Italy., Symons R; Department of Radiology, University Hospital Leuven, Leuven, Belgium., Tat E; Division of Cardiology, Loyola University of Chicago, Chicago, IL, USA., Timpani M; UOC Radiologia, Ospedale 'F. Spaziani', Frosinone, Italy., Todiere G; U.O.C. Risonanza Magnetica per Immagini, Fondazione G. Monasterio CNR-Regione Toscana Pisa, Pisa, Italy., Valentini A; Department of Radiology, Fondazione IRCCS Policlinico S.Matteo, Pavia, Italy., Varga-Szemes A; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA., Volpe A; Department of Cardiology, Citta` della salute e della Scienza - Ospedale Molinette, Turin, Italy., Fusini L; Centro Cardiologico Monzino IRCCS, University of Milan, Milan, Italy., Guaricci AI; Institute of Cardiovascular Disease, Department of Emergency and Organ Transplantation, University Hospital Policlinico of Bari, Bari, Italy., Schwitter J; Cardiovascular Department, CMR Center, University Hospital Lausanne, CHUV, Lausanne, Switzerland.; Faculty of Biology and Medicine, Lausanne University, UniL, Lausanne, Switzerland., Pontone G; Centro Cardiologico Monzino IRCCS, University of Milan, Milan, Italy.
Jazyk:	angličtina
Zdroj:	European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2023 Mar 21; Vol. 24 (4), pp. 472-482.
DOI:	10.1093/ehjci/jeac124
Abstrakt:	Aims: Right ventricular systolic dysfunction (RVSD) is an important determinant of outcomes in heart failure (HF) cohorts. While the quantitative assessment of RV function is challenging using 2D-echocardiography, cardiac magnetic resonance (CMR) is the gold standard with its high spatial resolution and precise anatomical definition. We sought to investigate the prognostic value of CMR-derived RV systolic function in a large cohort of HF with reduced ejection fraction (HFrEF). Methods and Results: Study cohort comprised of patients enrolled in the CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DefibrillAtor ThErapy registry who had HFrEF and had simultaneous baseline CMR and echocardiography (n = 2449). RVSD was defined as RV ejection fraction (RVEF) <45%. Kaplan-Meier curves and cox regression were used to investigate the association between RVSD and all-cause mortality (ACM). Mean age was 59.8 ± 14.0 years, 42.0% were female, and mean left ventricular ejection fraction (LVEF) was 34.0 ± 10.8. Median follow-up was 959 days (interquartile range: 560-1590). RVSD was present in 936 (38.2%) and was an independent predictor of ACM (adjusted hazard ratio = 1.44; 95% CI [1.09-1.91]; P = 0.01). On subgroup analyses, the prognostic value of RVSD was more pronounced in NYHA I/II than in NYHA III/IV, in LVEF <35% than in LVEF ≥35%, and in patients with renal dysfunction when compared to those with normal renal function. Conclusion: RV systolic dysfunction is an independent predictor of ACM in HFrEF, with a more pronounced prognostic value in select subgroups, likely reflecting the importance of RVSD in the early stages of HF progression. Competing Interests: Conflict of interest: S.J.A. is supported by NIH 2R01 HL12766105 & 1R21 EB030654 and receives royalty fees from Elsevier. Carlo De Cecco received grant by Siemens. G.P. received institutional fees by General Electric, Bracco, Heartflow, Medtronic, Bayer, Bhoeringher. J.S. received research support by Bayer Healthcare Switzerland. U.J.S. received grant by Astellas, Bayer, General Electric, and Siemens Healthcare, personal fees by Guerbet, speaking honorarium by Heartflow. A.V.-S. received grant by Siemens Healthcare and personal fees by Elucid Bioimaging. The other authors have nothing to disclose. (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Databáze:	MEDLINE
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