Biomaterial-Based Therapeutic Approaches to Osteoarthritis and Cartilage Repair Through Macrophage Polarization.
| Autor: | Das P; Department of Microbiology, School of Life Science and Biotechnology, Adamas University, Kolkata, 700126, India., Jana S; Department of Veterinary Physiology, West Bengal University of Animal and Fishery Sciences, 700037, Kolkata, India., Kumar Nandi S; Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, 700037, Kolkata, India. |
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| Jazyk: | angličtina |
| Zdroj: | Chemical record (New York, N.Y.) [Chem Rec] 2022 Sep; Vol. 22 (9), pp. e202200077. Date of Electronic Publication: 2022 Jul 05. |
| DOI: | 10.1002/tcr.202200077 |
| Abstrakt: | There is an ever-increasing clinical and socioeconomic burden associated with cartilage lesions & osteoarthritis (OA). Its progression, chondrocyte death & hypertrophy are all facilitated by inflamed synovium & joint environment. Due to their capacity to switch between pro- & anti-inflammatory phenotypes, macrophages are increasingly being recognized as a key player in the healing process, which has been largely overlooked in the past. A biomaterial's inertness has traditionally been a goal while developing them in order to reduce the likelihood of adverse reactions from the host organism. A better knowledge of how macrophages respond to implanted materials has made it feasible to determine the biomaterial architectural parameters that control the host response & aid in effective tissue integration. Thus, this review summarizes novel therapeutic techniques for avoiding OA or increasing cartilage repair & regeneration that might be developed using new technologies tuning macrophages into desirable functional phenotypes. (© 2022 The Chemical Society of Japan & Wiley-VCH GmbH.) |
| Databáze: | MEDLINE |
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