Determination of essential biomarkers in lung cancer: a real-world data study in Spain with demographic, clinical, epidemiological and pathological characteristics.

Autor: Provencio M; Medical Oncology Department, Hospital Universitario Puerta de Hierro-Majadahonda, C/ Manuel de Falla 1, Majadahonda, 28222, Madrid, Spain. mprovenciop@gmail.com., Cobo M; Hospital Regional Universitario de Málaga, Málaga, Spain., Rodriguez-Abreu D; Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain., Calvo V; Medical Oncology Department, Hospital Universitario Puerta de Hierro-Majadahonda, C/ Manuel de Falla 1, Majadahonda, 28222, Madrid, Spain., Carcereny E; Catalan Institute of Oncology, Hospital Universitari Germans Trias i Pujol, B-ARGO, IGTP, Badalona, Spain., Cantero A; Hospital Regional Universitario de Málaga, Málaga, Spain., Bernabé R; Hospital Universitario Virgen del Rocio, Sevilla, Spain., Benitez G; Hospital Universitario Insular de Gran Canaria, Las Palmas de Gran Canaria, Spain., Castro RL; Hospital Clínico Universitario de Valladolid, Valladolid, Spain., Massutí B; Hospital General Universitario de Alicante, Alicante, Spain., Del Barco E; Hospital Universitario de Salamanca, Salamanca, Spain., García Campelo R; Complejo Hospitalario Universitario A Coruña, A Coruña, Spain., Guirado M; Hospital General Universitario de Elche, Elche, Spain., Camps C; Hospital General Universitario de Valencia, Valencia, Spain.; Universidad de Valencia, Valencia, Spain.; CIBERONC, Madrid, Spain., Ortega AL; Hospital Universitario de Jaén, Jaén, Spain., González Larriba JL; Hospital Universitario Clínico San Carlos, Madrid, Spain., Sánchez A; Hospital Provincial de Castellón, Castellón, Spain., Casal J; Complexo Hospitalario de Vigo, Vigo, Spain., Sala MA; OSI Bilbao Basurto, Bibao, Spain., Juan-Vidal O; Hospital Universitario y Politécnico La Fe, Valencia, Spain., Bosch-Barrera J; Catalan Institute of Oncology, Hospital Universitari Dr. Josep Trueta, Girona, Spain., Oramas J; Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain., Dómine M; Hospital Universitario Fundación Jiménez Díaz. IIS-FJD, Madrid, Spain., Trigo JM; Hospital Universitario Virgen de la Victoria, Málaga, Spain., Blanco R; Consorci Sanitari de Terrassa, Barcelona, Spain., Calzas J; Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain., Morilla I; Complejo Hospitalario de Navarra, Navarra, Spain., Padilla A; Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain., Pimentao J; Department of Electrical Engineering, NOVA School of Science and Technology, Universidade Nova de Lisboa, Lisbon, Portugal., Sousa PA; Department of Electrical Engineering, NOVA School of Science and Technology, Universidade Nova de Lisboa, Lisbon, Portugal., Torrente M; Medical Oncology Department, Hospital Universitario Puerta de Hierro-Majadahonda, C/ Manuel de Falla 1, Majadahonda, 28222, Madrid, Spain.
Jazyk: angličtina
Zdroj: BMC cancer [BMC Cancer] 2022 Jul 05; Vol. 22 (1), pp. 732. Date of Electronic Publication: 2022 Jul 05.
DOI: 10.1186/s12885-022-09830-8
Abstrakt: Background: The survival of patients with lung cancer has substantially increased in the last decade by about 15%. This increase is, basically, due to targeted therapies available for advanced stages and the emergence of immunotherapy itself. This work aims to study the situation of biomarker testing in Spain.
Patients and Methods: The Thoracic Tumours Registry (TTR) is an observational, prospective, registry-based study that included patients diagnosed with lung cancer and other thoracic tumours, from September 2016 to 2020. This TTR study was sponsored by the Spanish Lung Cancer Group (GECP) Foundation, an independent, scientific, multidisciplinary oncology society that coordinates more than 550 experts and 182 hospitals across the Spanish territory.
Results: Nine thousand two hundred thirty-nine patients diagnosed with stage IV non-small cell lung cancer (NSCLC) between 2106 and 2020 were analysed. 7,467 (80.8%) were non-squamous and 1,772 (19.2%) were squamous. Tumour marker testing was performed in 85.0% of patients with non-squamous tumours vs 56.3% in those with squamous tumours (p-value < 0.001). The global testing of EGFR, ALK, and ROS1 was 78.9, 64.7, 35.6% respectively, in non-squamous histology. PDL1 was determined globally in the same period (46.9%), although if we focus on the last 3 years it exceeds 85%. There has been a significant increase in the last few years of all determinations and there are even close to 10% of molecular determinations that do not yet have targeted drug approval but will have it in the near future. 4,115 cases had a positive result (44.5%) for either EGFR, ALK, KRAS, BRAF, ROS1, or high PDL1.
Conclusions: Despite the lack of a national project and standard protocol in Spain that regulates the determination of biomarkers, the situation is similar to other European countries. Given the growing number of different determinations and their high positivity, national strategies are urgently needed to implement next-generation sequencing (NGS) in an integrated and cost-effective way in lung cancer.
(© 2022. The Author(s).)
Databáze: MEDLINE
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