| Autor: |
Bich Thi Le H; Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam.; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh city, Vietnam., Viet Ho D; Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam., Minh Nguyen H; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam., Tuan Le A; Vietnam National Museum of Nature, VAST, Mien Trung Institute for Scientific Research, Hue City, Vietnam., Tran TVA; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh city, Vietnam., Nguyen HT; Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Hue City, Vietnam. |
| Abstrakt: |
A new spirostanol steroid, aspidiata A ( 1 ), and a new spirostanol steroidal saponin, aspidiata B ( 2 ), along with three known compounds, paris saponin VII ( 3 ), daucosterol ( 4 ), and (25 R )-spirostane-1 β ,2 β ,3 β ,4 β ,5 β ,6 β -hexol ( 5 ), were isolated from whole plants of Aspidistra triradiata collected in Vietnam. Their chemical structures were established by spectroscopic analysis and comparison with previously published data. Compound 3 showed strong cytotoxicity against LU-1, Hep-G2, MCF-7, and KB human cancer cell lines with half maximal inhibitory concentration (IC 50 ) values ranging from 0.57 to 1.23 µM. Compound 5 exhibited weak cytotoxic activity against the LU-1 cell line, with an IC 50 value of 95.81 µM. |
