The hypolipidemic, anti-inflammatory and antioxidant effect of Kavolì® aqueous extract, a mixture of Brassica oleracea leaves, in a rat model of NAFLD.

Autor: Vornoli A; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Pisa Unit, Research Area of Pisa, Via Moruzzi 1, 56124, Pisa, Italy., Vizzarri F; Department of Agro-Environmental and Territorial Sciences (Disaat), University of Bari, Via Amendola 165/A, 70126, Bari, Italy; National Agricultural and Food Centre Nitra, Hlohovecká 2, 95141, Lužianky, Slovak Republic., Della Croce CM; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Pisa Unit, Research Area of Pisa, Via Moruzzi 1, 56124, Pisa, Italy., Grande T; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Pisa Unit, Research Area of Pisa, Via Moruzzi 1, 56124, Pisa, Italy., Palazzo M; Department of Agricultural, Environmental and Food Sciences, University of Molise, Via De Sanctissnc, 86100, Campobasso, Italy., Árvay J; Institute of Food Sciences, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra. Tr. A Hlinku 2, 949 76, Nitra, Slovak Republic., Pucci L; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Pisa Unit, Research Area of Pisa, Via Moruzzi 1, 56124, Pisa, Italy., Gabriele M; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Pisa Unit, Research Area of Pisa, Via Moruzzi 1, 56124, Pisa, Italy., Matteucci M; Institute of Life Sciences, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà, 33, 56127, Pisa, Italy., Paolini M; Department of Pharmacology and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Zamboni, 33, 40126, Bologna, Italy., Longo V; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Pisa Unit, Research Area of Pisa, Via Moruzzi 1, 56124, Pisa, Italy., Pozzo L; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Pisa Unit, Research Area of Pisa, Via Moruzzi 1, 56124, Pisa, Italy. Electronic address: luisa.pozzo@ibba.cnr.it.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2022 Sep; Vol. 167, pp. 113261. Date of Electronic Publication: 2022 Jul 03.
DOI: 10.1016/j.fct.2022.113261
Abstrakt: Herein we characterized the bioactive metabolites of the aqueous extract of Kavolì®, a commercial product composed of a mixture of Brassica oleracea leaves, and assessed its potential ameliorating effects in a rat model of non-alcoholic fatty liver disease (NAFLD). Kavolì® extract showed high levels of bioactive compounds and strong in vitro antioxidant activities. Chlorogenic and neochlorogenic acids were identified as the most representative polyphenols. The administration of brassica extract to steatotic rats significantly ameliorated the levels of blood lipids and transaminases, and lipid content and inflammatory markers in liver. Oxidative stress parameters were significantly improved in both liver and brain of steatotic rats. Moreover, plasma and feces levels of short chain fatty acids (SCFAs) were bring back close to control values by Kavolì® treatment, in spite of high fat diet/streptozotocin (HFD/STZ)-induced alterations. The efficacy of Kavolì® in treating hypercholesterolemia, reducing the level of inflammation and cardiovascular disease biomarkers, steatosis and oxidative stress parameters, as well as the ability in modulating SCFAs levels is probably related to the bioactive compounds of the water extract administered to the rat model of NAFLD. In particular, the ameliorating effects are largely attributable to the high content in polyphenols observed in our study.
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Databáze: MEDLINE
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