Clinical and pathologic features of primary membranous nephropathy in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group.

Autor: Yildiz A; Department of Nephrology, Med Fac, Uludag Univ, Bursa, Turkey., Ulu S; Department of Nephrology, Med Fac, Afyon Kocatepe Univ, Afyon, Turkey., Oruc A; Department of Nephrology, Med Fac, Uludag Univ, Bursa, Turkey., Ucar AR; Department of Nephrology, Istanbul Fac Med, Istanbul Univ, Istanbul, Turkey., Ozturk S; Department of Nephrology, Haseki Training and Res Hosp, Istanbul, Turkey., Alagoz S; Department of Nephrology, Cerrahpasa Med Fac, Istanbul Univ, Istanbul, Turkey., Eren N; Department of Nephrology, Med Fac, Kocaeli Univ, Kocaeli, Turkey., Kocyigit I; Department of Nephrology, Med Fac, Erciyes Univ, Kayseri, Turkey., Koksal Cevher S; Department of Nephrology, Ankara Numune Training and Res Hosp, Ankara, Turkey., Haras AB; Department of Nephrology, Dr Lutfi Kirdar Kartal Training and Res Hosp, Istanbul, Turkey., Sumnu A; Department of Nephrology, Med Fac, Medipol Univ, Istanbul, Turkey., Arinsoy T; Department of Nephrology, Med Fac, Gazi Univ, Ankara, Turkey., Sahin G; Department of Nephrology, Med Fac, Eskisehir Osmangazi Univ, Eskisehir, Turkey., Suleymanlar G; Department of Nephrology, Med Fac, Akdeniz Univ, Antalya, Turkey., Cavdar C; Department of Nephrology, Med Fac, Dokuz Eylul Univ, Izmir, Turkey., Kumru Sahin G; Med Fac, Ibni Sina Hosp, Ankara Univ, Ankara, Turkey., Kurultak I; Department of Nephrology, Med Fac, Trakya Univ, Edirne, Turkey., Unsal A; Department of Nephrology, Hamidiye Sisli Etfal Training and Res Hosp, Istanbul, Turkey., Sahin G; Department of Nephrology, Sultan Abdulhamit Han Res and Training Hosp, Istanbul, Turkey., Kazan S; Department of Nephrology, Med Fac, Afyon Kocatepe Univ, Afyon, Turkey., Tatar E; Department of Nephrology, Bozyaka Training & Res Hosp, Izmir, Turkey., Dıkec M; Department of Nephrology, Bakirkoy Sadi Konuk Training and Res Hosp, Istanbul, Turkey., Dursun B; Department of Nephrology, Med Fac, Pamukkale Univ, Denizli, Turkey., Sayarlioglu H; Department of Nephrology, Med Fac, Sutcu Imam Univ, Kahramanmaras, Turkey., Turkmen K; Department of Nephrology, Meram Med Fac, Necmettin Erbakan Univ, Konya, Turkey., Artan AS; Department of Nephrology, Med Fac, Bezmialem Vakif Univ, Istanbul, Turkey., Aktas N; Department of Nephrology, Med Fac, Bezmialem Vakif Univ, Istanbul, Turkey., Yilmaz Z; Department of Nephrology, Med Fac, Dicle Univ, Diyarbakir, Turkey., Behlul A; Department of Nephrology, Burhan Nalbantoglu State Hosp, Nicosia, Cyprus., Dheir H; Department of Nephrology, Med Fac, Sakarya Univ, Sakarya, Turkey., Kutlay S; Med Fac, Ibni Sina Hosp, Ankara Univ, Ankara, Turkey., Seyahi N; Department of Nephrology, Cerrahpasa Med Fac, Istanbul Univ, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Renal failure [Ren Fail] 2022 Dec; Vol. 44 (1), pp. 1048-1059.
DOI: 10.1080/0886022X.2022.2079526
Abstrakt: Background: We aimed to evaluate the features of primary membranous nephropathy (MNP) in Turkish people.
Methods: This is a retrospective analysis of patients with biopsy-proven primary MNP. We obtained the data collected between 2009 and 2019 in the primary glomerulonephritis registry of the Turkish Society of Nephrology Glomerular Diseases Study Group (TSN-GOLD). Patients with a secondary cause for MNP were excluded. Clinical, demographic, laboratory, and histopathological findings were analyzed.
Results: A total of 995 patients with primary MNP were included in the analyses. Males constituted the majority (58.8%). The mean age was 48.4 ± 13.9 years. The most common presentation was the presence of nephrotic syndrome (81.7%) and sub nephrotic proteinuria (10.3%). Microscopic hematuria was detected in one-third of patients. The median estimated glomerular filtration rate (eGFR) was 100.6 mL/min/1.73 m 2 (IQR, 75.4-116.3), and median proteinuria was 6000 mg/d (IQR, 3656-9457). Serum C3 and C4 complement levels were decreased in 3.7 and 1.7% of patients, respectively. Twenty-four (2.4%) patients had glomerular crescents in their kidney biopsy samples. Basal membrane thickening was detected in 93.8% of cases under light microscopy. Mesangial proliferation and interstitial inflammation were evident in 32.8 and 55.9% of the patients, respectively. The most commonly detected depositions were IgG (93%), C3 complement (68.8%), and kappa and lambda immunoglobulin light chains (70%). Although renal functions were normal at presentation, vascular, interstitial, and glomerular findings were more prominent on biopsy in hypertensive patients. No significant effect of BMI on biopsy findings was observed.
Conclusions: Despite some atypical findings, the main features of primary MNP in Turkey were similar to the published literature. This is the largest MNP study to date conducted in Turkish people.
Databáze: MEDLINE
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