Effects of Hydroxyurea on Skeletal Muscle Energetics and Function in a Mildly Anemic Mouse Model.
| Autor: | Michel CP; CRMBM, CNRS, Aix Marseille University, Marseille, France., Messonnier LA; Laboratoire Interuniversitaire de Biologie de la Motricité, Université Savoie Mont Blanc, Chambéry, France., Giannesini B; CRMBM, CNRS, Aix Marseille University, Marseille, France., Chatel B; CRMBM, CNRS, Aix Marseille University, Marseille, France.; Laboratoire Interuniversitaire de Biologie de la Motricité, Université Savoie Mont Blanc, Chambéry, France., Vilmen C; CRMBM, CNRS, Aix Marseille University, Marseille, France., Le Fur Y; CRMBM, CNRS, Aix Marseille University, Marseille, France., Bendahan D; CRMBM, CNRS, Aix Marseille University, Marseille, France. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Frontiers in physiology [Front Physiol] 2022 Jun 15; Vol. 13, pp. 915640. Date of Electronic Publication: 2022 Jun 15 (Print Publication: 2022). |
| DOI: | 10.3389/fphys.2022.915640 |
| Abstrakt: | Hydroxyurea (HU) is a ribonucleotide reductase inhibitor most commonly used as a therapeutic agent in sickle cell disease (SCD) with the aim of reducing the risk of vaso-occlusion and improving oxygen transport to tissues. Previous studies suggest that HU may be even beneficial in mild anemia. However, the corresponding effects on skeletal muscle energetics and function have never been reported in such a mild anemia model. Seventeen mildly anemic HbAA Townes mice were subjected to a standardized rest-stimulation (transcutaneous stimulation)-protocol while muscle energetics using 31 Phosphorus magnetic resonance spectroscopy and muscle force production were assessed and recorded. Eight mice were supplemented with hydroxyurea (HU) for 6 weeks while 9 were not (CON). HU mice displayed a higher specific total force production compared to the CON, with 501.35 ± 54.12 N/mm 3 and 437.43 ± 57.10 N/mm 3 respectively (+14.6%, p < 0.05). Neither the total rate of energy consumption nor the oxidative metabolic rate were significantly different between groups. The present results illustrated a positive effect of a HU chronic supplementation on skeletal muscle function in mice with mild anemia. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Michel, Messonnier, Giannesini, Chatel, Vilmen, Le Fur and Bendahan.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|