Serological Response to BNT162b2 Anti-SARS-CoV-2 Vaccination in Patients with Inflammatory Rheumatic Diseases: Results From the RHEUVAX Cohort.

Autor:	Mauro D; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Ciancio A; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Di Vico C; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Passariello L; Unit of Clinical and Molecular Pathology, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Rozza G; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Pasquale MD; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Pantano I; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Cannistrà C; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Bucci L; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Scriffignano S; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Riccio F; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Patrone M; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Scalise G; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Ruscitti P; Rheumatology Unit, Department of Biotechnological & Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Montemurro MV; Clinical Directorate, University Hospital of Università degli Studi della Campania 'L. Vanvitelli', Naples, Italy., Giordano A; Head Office, University Hospital of Università degli Studi della Campania 'L. Vanvitelli', Naples, Italy., Vietri MT; Unit of Clinical and Molecular Pathology, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy., Ciccia F; Rheumatology Unit, Department of Precision Medicine, Università degli Studi della Campania 'L.Vanvitelli', Naples, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2022 Jun 17; Vol. 13, pp. 901055. Date of Electronic Publication: 2022 Jun 17 (Print Publication: 2022).
DOI:	10.3389/fimmu.2022.901055
Abstrakt:	Objective: In the light of the current COVID-19 epidemic and the availability of effective vaccines, this study aims to identify factors associated with non-response to anti-SARS-CoV-2 vaccines as immunological alteration associated with immune rheumatic diseases (IRD) and immunosuppressive medications may impair the response to vaccination. Methods: Volunteers in the health profession community with IRD, age, and sex-matched controls (CTRL) who underwent vaccination with two doses of BNT162b2 were recruited for this study. Anti-Trimeric Spike protein antibodies were assayed eight ± one weeks after the second vaccine dose. Univariate and logistic regression analyses were performed to identify factors independently associated with non-response and low antibody titers. Results: Samples were obtained from 237 IRD patients (m/f 73/164, mean age 57, CI 95% [56-59]): 4 autoinflammatory diseases (AI), 62 connective tissue diseases (CTD), 86 rheumatoid arthritis (RA), 71 spondylarthritis (SpA) and 14 vasculitis (Vsc). 232 CTRL were recruited (m/f 71/161, mean age 57, CI 95% [56-58]). Globally, IRD had a lower seroconversion rate (88.6% vs 99.6%, CI 95% OR [1.61-5.73], p<0.001) and lower antibody titer compared to controls (median (IQR) 403 (131.5-1012) versus 1160 (702.5-1675), p<0.001). After logistic regression, age, corticosteroid (CCS), Abatacept and Mycophenolate Mofetil (MMF) use were associated with non-response. Lower antibody titer was associated with the use of MMF, ABA, CCS, Rituximab, tumor necrosis factor inhibitor, JAK inhibitors, and higher age. Conclusion: The response to anti-SARS-CoV-2 vaccines is often impaired in IRD patients under treatment and may pose them at higher risk of severe COVID-19. Specific vaccination protocols are desirable for these patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Mauro, Ciancio, Di Vico, Passariello, Rozza, Pasquale, Pantano, Cannistrà, Bucci, Scriffignano, Riccio, Patrone, Scalise, Ruscitti, Montemurro, Giordano, Vietri and Ciccia.)
Databáze:	MEDLINE
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