Low-Cost Genetic and Clinical Predictors of Response and Toxicity of Platinum-Based Chemotherapy in Advanced Non-Small Cell Lung Cancer.

Autor: Spasic J; Clinic for Medical Oncology, Institute for Oncology and Radiology of Serbia, Serbia., Cavic M; Department of Experimental Oncology, Institute for Oncology and Radiology of Serbia, Serbia., Stanic N; Clinic for Medical Oncology, Institute for Oncology and Radiology of Serbia, Serbia., Zaric B; Faculty of Medicine, University of Novi Sad, Serbia.; Institute for Pulmonary Diseases of Vojvodina, Serbia., Kovacevic T; Faculty of Medicine, University of Novi Sad, Serbia.; Institute for Pulmonary Diseases of Vojvodina, Serbia., Radosavljevic D; Clinic for Medical Oncology, Institute for Oncology and Radiology of Serbia, Serbia., Nagorni-Obradovic L; Faculty of Medicine, University of Belgrade, Serbia.; Clinic for Pulmonology, University Clinical Centre of Serbia, Serbia.
Jazyk: angličtina
Zdroj: Dose-response : a publication of International Hormesis Society [Dose Response] 2022 Jun 28; Vol. 20 (2), pp. 15593258221111666. Date of Electronic Publication: 2022 Jun 28 (Print Publication: 2022).
DOI: 10.1177/15593258221111666
Abstrakt: Background: This study aimed to evaluate for the first time whether certain genetic and clinical factors could serve as minimally invasive predictors of survival and toxicity to platinum-based chemotherapy in advanced lung adenocarcinoma.
Methods: The study included 121 advanced lung adenocarcinoma patients treated with platinum-based dublets until progression or unacceptable toxicity. Response was evaluated using standard radiological methods and toxicity graded according to the Common Terminology Criteria for Adverse Events (CTCAE) v5.0. Genotyping was performed using PCR-RFLP. Statistical significance was set at P < .05.
Results: No significant influence of the examined polymorphisms on the occurrence of high-grade toxicity was detected. However, TP53 72Pro allele carriers were more prone to nausea (P = .037) and thrombocytopenia (P = .051). Anemia and neuropathy occurred more frequently in XRCC1 399Arg allele carriers (Pearson χ2 test, P = .025 and P = .004 respectively). RAD51 135CC carriers were significantly more prone to neutropenia (P = .027).
Conclusions: A set of easily determined genetic and clinical predictors of survival and specific toxicity profiles of platinum-based chemotherapy in advanced lung adenocarcinoma were determined in this study, which might be useful for the construction of population-specific, time- and cost-efficient prognostic and predictive algorithms.
Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2022.)
Databáze: MEDLINE
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