Exposures to low-levels of fine particulate matter are associated with acute changes in heart rate variability, cardiac repolarization, and circulating blood lipids in coronary artery disease patients.

Autor: Mirowsky JE; Department of Chemistry, SUNY College of Environmental Science and Forestry, Syracuse, NY, USA; Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC, USA. Electronic address: jmirowsk@esf.edu., Carraway MS; Department of Medicine, Pulmonary and Critical Care Medicine, Durham VA Medical Center, Durham, NC, USA., Dhingra R; Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC, USA; Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, USA., Tong H; Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC, USA., Neas L; Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC, USA., Diaz-Sanchez D; Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC, USA., Cascio WE; Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC, USA., Case M; Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC, USA., Crooks JL; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA., Hauser ER; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA; Cooperative Studies Program Epidemiology Center, Durham Veterans Affairs Medical Center, Durham, NC, USA., Dowdy ZE; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA., Kraus WE; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA; Division of Cardiology, Department of Medicine, School of Medicine, Duke University, Durham, NC, USA., Devlin RB; Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC, USA.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2022 Nov; Vol. 214 (Pt 1), pp. 113768. Date of Electronic Publication: 2022 Jun 30.
DOI: 10.1016/j.envres.2022.113768
Abstrakt: Exposure to air pollution is a major risk factor for cardiovascular disease, disease risk factors, and mortality. Specifically, particulate matter (PM), and to some extent ozone, are contributors to these effects. In addition, exposures to these pollutants may be especially dangerous for susceptible populations. In this repeated-visit panel study, cardiovascular markers were collected from thirteen male participants with stable coronary artery disease. For 0-4 days prior to the health measurement collections, daily concentrations of fine PM (PM 2.5 ) and ozone were obtained from local central monitoring stations located near the participant's homes. Then, single (PM 2.5 ) and two-pollutant (PM 2.5 and ozone) models were used to assess whether there were short-term changes in cardiovascular health markers. Per interquartile range increase in PM 2.5 , there were decrements in several heart rate variability metrics, including the standard deviation of the normal-to-normal intervals (lag 3, -5.8%, 95% confidence interval (CI) = -11.5, 0.3) and root-mean squared of successive differences (five day moving average, -8.1%, 95% CI = -15.0, -0.7). In addition, increases in PM 2.5 were also associated with changes in P complexity (lag 1, 4.4%, 95% CI = 0.5, 8.5), QRS complexity (lag 1, 4.9%, 95% CI = 1.4, 8.5), total cholesterol (five day moving average, -2.1%, 95% CI = -4.1, -0.1), and high-density lipoprotein cholesterol (lag 2, -1.6%, 95% CI = -3.1, -0.1). Comparisons to our previously published work on ozone were conducted. We found that ozone affected inflammation and endothelial function, whereas PM 2.5 influenced heart rate variability, repolarization, and lipids. All the health changes from these two studies were found at concentrations below the United States Environmental Protection Agency's National Ambient Air Quality Standards. Our results imply clear differences in the cardiovascular outcomes observed with exposure to the two ubiquitous air pollutants PM 2.5 and ozone; this observation suggests different mechanisms of toxicity for these exposures.
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Databáze: MEDLINE
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