[Histological, immunohistochemical and molecular study of a paratesticular dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features].

Autor:	Machado I; Departamento de Patología, Instituto Valenciano de Oncología, Valencia, España; Departamento de Patología, Patologika Laboratorio, Hospital Quirón-Salud, Valencia, España. Electronic address: isidro.machado@uv.es., Martí Ibor E; Departamento de Patología, Patologika Laboratorio, Hospital Quirón-Salud, Valencia, España; Departamento de Patología, Hospital Peset Alexandre, Valencia, España., Berbegall AP; Departamento de Patología, Patologika Laboratorio, Hospital Quirón-Salud, Valencia, España., Alcácer Fernández-Coronado J; Departamento de Patología, Patologika Laboratorio, Hospital Quirón-Salud, Valencia, España., Claramunt R; Departamento de Biología Molecular, Instituto Valenciano de Oncología, Valencia, España., Duarte Novo JE; Servicio de Urología, Hospital San Rafael, A Coruña, España., Mosquera Reboredo J; Departamento de Patología, Hospital San Rafael, A Coruña, España., Concha López Á; Departamento de Patología, Hospital San Rafael, A Coruña, España., Alcácer García J; Departamento de Patología, Patologika Laboratorio, Hospital Quirón-Salud, Valencia, España.
Jazyk:	Spanish; Castilian
Zdroj:	Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia [Rev Esp Patol] 2022 Jul-Sep; Vol. 55 (3), pp. 212-217. Date of Electronic Publication: 2021 Oct 07.
DOI:	10.1016/j.patol.2021.07.002
Abstrakt:	We report the histological, immunohistochemical, and molecular findings of a dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features occurring in the paratesticular region. Histologically, the dedifferentiated component closely resembled an inflammatory myofibroblastic tumor. The neoplastic cells were positive for smooth muscle actin with focal CD56, CD99, Bcl2 and EMA expression. WT1, calretinin, myogenin, CK(AE1/AE3), desmin, H-caldesmon, CD34, ALK, CKIT, DOG1, MUC4 and STAT6 were negative. MDM2 showed diffuse and strong nuclear positivity in neoplastic cells and fluorescence in situ hybridization (FISH) revealed amplified MDM2 (high level) but no SYT rearrangement. Although a lipomatous component was evident macroscopically, well-differentiated liposarcomatous components were not evident in the section examined. Dedifferentiated liposarcoma can have prominent inflammatory myofibroblastic tumor-like features. Pathologists should be aware of this histological variant in order to avoid misdiagnosing dedifferentiated liposarcoma as inflammatory myofibroblastic tumor or other spindle cell tumors which have different behavioral patterns and treatment requirements. (Copyright © 2021 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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