The bad rainbow of COVID-19 time: effects on glucose metabolism in children and adolescents with obesity and overweight.

Autor: Giannini C; Department of Pediatrics, University of Chieti, Chieti, Italy.; Clinical Research Center, 'G. d'Annunzio' Foundation, University of Chieti, Chieti, Italy., Polidori N; Department of Pediatrics, University of Chieti, Chieti, Italy. nella.polidori@hotmail.it., Chiarelli F; Department of Pediatrics, University of Chieti, Chieti, Italy.; Clinical Research Center, 'G. d'Annunzio' Foundation, University of Chieti, Chieti, Italy., Mohn A; Department of Pediatrics, University of Chieti, Chieti, Italy.; Clinical Research Center, 'G. d'Annunzio' Foundation, University of Chieti, Chieti, Italy.
Jazyk: angličtina
Zdroj: International journal of obesity (2005) [Int J Obes (Lond)] 2022 Sep; Vol. 46 (9), pp. 1694-1702. Date of Electronic Publication: 2022 Jul 01.
DOI: 10.1038/s41366-022-01164-6
Abstrakt: Background: COVID-19 restriction measurements have enhanced the obesity status in the pediatric population which might further contribute to obesity-related glucose-insulin metabolism alterations. Therefore, we retrospectively compared anthropometric and OGTT data on children with obesity during the 13 years before and during the COVID-19 pandemic.
Subjects/methods: Data from 741 children with obesity and overweight were retrieved and clustered into seven groups starting from year 2008-2009 until 2020-2021. Differences in anthropometric measurements and glucose/insulin metabolism were evaluated between the different groups.
Results: Children with overweight and obesity in the COVID-19 restriction group did not present increased values of SDS-Body Mass Index (BMI). Significantly higher values for Waist Circumference (WC), SDS-WC, Waist/Height ratio (WHtR), and body mass fat were detected in these children (all P < 0.01). Fasting glycaemia, glucose, and insulin excursions were significantly higher compared to pre- pandemic children (all P < 0.01). Insulin resistance was higher while insulin secretion was lower (all P < 0.01) determining a significantly higher percentage of impaired glucose tolerance in the COVID-19 restriction group (P < 0.002). Furthermore, High-Density Lipoprotein (HDL) cholesterol was significantly lower (P < 0.01) and SDS for systolic and diastolic blood pressure values were significantly higher (P = 0.03 and P = 0.02, respectively).
Conclusions: COVID-19 restriction measurements determined profound alterations in glucose and insulin metabolism in children with obesity and overweight. Urgent strategies are needed in order to reverse COVID-19 restriction measures' effects on glucose and insulin metabolism.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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