Focal epilepsy disrupts spindle structure and function.

Autor: Schiller K; Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada.; Department of Pediatrics, Hospital Group Ostallgaeu-Kaufbeuren, Kaufbeuren, Germany., Avigdor T; Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada., Abdallah C; Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada., Sziklas V; Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada., Crane J; Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada., Stefani A; Department of Neurology, Medical University Innsbruck, Innsbruck, Austria., Peter-Derex L; Center for Sleep Medicine and Respiratory Diseases, Croix-Rousse Hospital, University Hospital of Lyon, Lyon 1 University, Lyon, France., Frauscher B; Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada. birgit.frauscher@mcgill.ca.; Department of Medicine and Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada. birgit.frauscher@mcgill.ca.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jul 01; Vol. 12 (1), pp. 11137. Date of Electronic Publication: 2022 Jul 01.
DOI: 10.1038/s41598-022-15147-0
Abstrakt: Sleep spindles are the hallmark of N2 sleep and are attributed a key role in cognition. Little is known about the impact of epilepsy on sleep oscillations underlying sleep-related functions. This study assessed changes in the global spindle rate in patients with epilepsy, analysed the distribution of spindles in relation to the epileptic focus, and performed correlations with neurocognitive function. Twenty-one patients with drug-resistant focal epilepsy (12 females; mean age 32.6 ± 10.7 years [mean ± SD]) and 12 healthy controls (3 females; 24.5 ± 3.3 years) underwent combined whole-night high-density electroencephalography and polysomnography. Global spindle rates during N2 were lower in epilepsy patients compared to controls (mean = 5.78/min ± 0.72 vs. 6.49/min ± 0.71, p = 0.02, d =  - 0.70). Within epilepsy patients, spindle rates were lower in the region of the epileptic focus compared to the contralateral region (median = 4.77/min [range 2.53-6.18] vs. 5.26/min [2.53-6.56], p = 0.02, rank biserial correlation RC =  - 0.57). This decrease was driven by fast spindles (12-16 Hz) (1.50/min [0.62-4.08] vs. 1.65/min [0.51-4.28], p = 0.002, RC =  - 0.76). The focal reduction in spindles was negatively correlated with two scales of attention (r =  - 0.54, p = 0.01; r =  - 0.51, p = 0.025). Patients with focal epilepsy show a reduction in global and local spindle rates dependent on the region of the epileptic focus. This may play a role in impaired cognitive functioning. Future work will show if the local reduction in spindles can be used as potential marker of the epileptic focus.
(© 2022. The Author(s).)
Databáze: MEDLINE
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