In-situ TD-GCMS measurements of oxidative products of monoterpenes at typical vaping temperatures: implications for inhalation exposure to vaping products.

Autor: Zhu J; Exposure and Biomonitoring Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada. jiping.zhu@hc-sc.gc.ca., Niu J; Exposure and Biomonitoring Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada., Das D; Exposure and Biomonitoring Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada., Cabecinha A; Office of Cannabis Science and Surveillance, Controlled Substances and Cannabis Branch, Health Canada, Ottawa, Canada., Abramovici H; Office of Cannabis Science and Surveillance, Controlled Substances and Cannabis Branch, Health Canada, Ottawa, Canada.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jun 30; Vol. 12 (1), pp. 11019. Date of Electronic Publication: 2022 Jun 30.
DOI: 10.1038/s41598-022-14236-4
Abstrakt: Vaping is gaining in popularity. However, there is still much that remains unknown about the potential risk and harms of vaping. Formation of oxidative products is one of such areas that are not well understood. In this study, we used an in-situ thermal desorption GC/MS method to investigate the formation of oxidative products of several monoterpenes at or below typical vaping temperatures. Among the five tested monoterpenes, the unchanged portion of the parent compound in the vapour varied from 97 to 98% for myrcene to 11-28% for terpinolene. The majority of formed oxidative products in the vapour have a molecular weight of 134 (loss of two hydrogens), 150 (insertion of one oxygen and loss of two hydrogen atoms) or 152 (insertion of one oxygen atom). Three products, likely to be p-(1-propenyl)-toluene, β-pinone and fenchol were also observed. This is the first in-situ thermal desorption GC/MS study to investigate the possible formation of oxidative products of monoterpenes, one of the major components in vaping liquids, at temperatures that are relevant to the vaping process. Although the toxicity of inhaling these oxidative products is not clear yet, allergic and irritation reactions associated with oxidized monoterpene oils are well documented. Therefore, potential adverse effects of inhaling these oxidative products during vaping could be investigated to help support human risk assessment.
(© 2022. Crown.)
Databáze: MEDLINE
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