Effect of vaccination on household transmission of SARS-CoV-2 Delta variant of concern.

Autor: Lyngse FP; Department of Economics & Center for Economic Behaviour and Inequality, University of Copenhagen, Copenhagen, Denmark. fpl@econ.ku.dk.; Danish Ministry of Health, Copenhagen, Denmark. fpl@econ.ku.dk.; Statens Serum Institut, Copenhagen, Denmark. fpl@econ.ku.dk., Mølbak K; Statens Serum Institut, Copenhagen, Denmark.; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Denwood M; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Christiansen LE; Department of Applied Mathematics and Computer Science, Dynamical Systems, Technical University of Denmark, Richard Petersens Plads, 324, DK-2800, Kgs. Lyngby, Denmark., Møller CH; Statens Serum Institut, Copenhagen, Denmark., Rasmussen M; Statens Serum Institut, Copenhagen, Denmark., Cohen AS; Statens Serum Institut, Copenhagen, Denmark., Stegger M; Statens Serum Institut, Copenhagen, Denmark., Fonager J; Statens Serum Institut, Copenhagen, Denmark., Sieber RN; Statens Serum Institut, Copenhagen, Denmark., Ellegaard KM; Statens Serum Institut, Copenhagen, Denmark., Nielsen C; Statens Serum Institut, Copenhagen, Denmark., Kirkeby CT; Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Jun 30; Vol. 13 (1), pp. 3764. Date of Electronic Publication: 2022 Jun 30.
DOI: 10.1038/s41467-022-31494-y
Abstrakt: Effective vaccines protect individuals by not only reducing the susceptibility to infection, but also reducing the infectiousness of breakthrough infections in vaccinated cases. To disentangle the vaccine effectiveness against susceptibility to infection (VE S ) and vaccine effectiveness against infectiousness (VE I ), we took advantage of Danish national data comprising 24,693 households with a primary case of SARS-CoV-2 infection (Delta Variant of Concern, 2021) including 53,584 household contacts. In this setting, we estimated VE S as 61% (95%-CI: 59-63), when the primary case was unvaccinated, and VE I as 31% (95%-CI: 26-36), when the household contact was unvaccinated. Furthermore, unvaccinated secondary cases with an infection exhibited a three-fold higher viral load compared to fully vaccinated secondary cases with a breakthrough infection. Our results demonstrate that vaccinations reduce susceptibility to infection as well as infectiousness, which should be considered by policy makers when seeking to understand the public health impact of vaccination against transmission of SARS-CoV-2.
(© 2022. The Author(s).)
Databáze: MEDLINE
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