Comparison between two antimicrobial photodynamic therapy protocols for oral candidiasis in patients undergoing treatment for head and neck cancer: A two-arm, single-blind clinical trial.

Autor: Fonseca LL; Department of Dentistry, Laboratório de Pesquisa em Saúde, Hospital Universitário Clemente Faria, Universidade Estadual de Montes Claros (Unimontes), 562 Av. Cula Mangabeira Santo Expedito, Montes Claros, Minas Gerais 39401-001, Brazil., Durães CP; Department of Dentistry, Laboratório de Pesquisa em Saúde, Hospital Universitário Clemente Faria, Universidade Estadual de Montes Claros (Unimontes), 562 Av. Cula Mangabeira Santo Expedito, Montes Claros, Minas Gerais 39401-001, Brazil., Menezes ASDS; Department of Dentistry, Laboratório de Pesquisa em Saúde, Hospital Universitário Clemente Faria, Universidade Estadual de Montes Claros (Unimontes), 562 Av. Cula Mangabeira Santo Expedito, Montes Claros, Minas Gerais 39401-001, Brazil., Tabosa ATL; Department of Dentistry, Laboratório de Pesquisa em Saúde, Hospital Universitário Clemente Faria, Universidade Estadual de Montes Claros (Unimontes), 562 Av. Cula Mangabeira Santo Expedito, Montes Claros, Minas Gerais 39401-001, Brazil., Barbosa CU; Department of Dentistry, Laboratório de Pesquisa em Saúde, Hospital Universitário Clemente Faria, Universidade Estadual de Montes Claros (Unimontes), 562 Av. Cula Mangabeira Santo Expedito, Montes Claros, Minas Gerais 39401-001, Brazil., Filho APS; Dilson Godinho Hospital, Montes Claros, Minas Gerais, Brazil., Souza DPSP; Institute of Agricultural Sciences, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil., Guimarães VHD; Institute of Agricultural Sciences, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil., Santos SHS; Institute of Agricultural Sciences, Universidade Federal de Minas Gerais (UFMG), Montes Claros, Minas Gerais, Brazil., de Paula AMB; Department of Dentistry, Laboratório de Pesquisa em Saúde, Hospital Universitário Clemente Faria, Universidade Estadual de Montes Claros (Unimontes), 562 Av. Cula Mangabeira Santo Expedito, Montes Claros, Minas Gerais 39401-001, Brazil., Farias LC; Department of Dentistry, Laboratório de Pesquisa em Saúde, Hospital Universitário Clemente Faria, Universidade Estadual de Montes Claros (Unimontes), 562 Av. Cula Mangabeira Santo Expedito, Montes Claros, Minas Gerais 39401-001, Brazil., Guimarães ALS; Department of Dentistry, Laboratório de Pesquisa em Saúde, Hospital Universitário Clemente Faria, Universidade Estadual de Montes Claros (Unimontes), 562 Av. Cula Mangabeira Santo Expedito, Montes Claros, Minas Gerais 39401-001, Brazil; Dilson Godinho Hospital, Montes Claros, Minas Gerais, Brazil. Electronic address: andreluizguimaraes@gmail.com.
Jazyk: angličtina
Zdroj: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2022 Sep; Vol. 39, pp. 102983. Date of Electronic Publication: 2022 Jun 27.
DOI: 10.1016/j.pdpdt.2022.102983
Abstrakt: Purpose This study aimed to compare the efficacy of Antimicrobial Photodynamic Therapy (aPDT) with 300 µmol/L of methylene blue and 8 µmol/L of curcumin on oral candidiasis patients with HNSCC undergoing treatment. Methods A two-arm, single-blind clinical trial was performed. Following verification for eligibility (n = 447), 108 patients were included in the study. The study consisted of a group that received aPDT with methylene blue (n = 57) and another that received aPDT with curcumin (n = 51). The patients rinsed their mouths with an aqueous solution of 300 µmol/L of methylene blue and 8 µmol/L of curcumin in four sessions, and then the lesion was scraped for the subsequent RT-qPCR. The primary outcome was that no cure was presented for oral candidiasis after treatment. The secondary result was reducing the number of sites affected by oral candidiasis. Results There was no difference in treatment failure evaluated by the necessity of drug prescription or Candida sp DNA quantification. However, clinically the methylene blue protocol reduced the number of infected anatomical sites compared to the curcumin protocol. Conclusion Methylene blue aPDT reduced the number of infected anatomical sites compared to curcumin.
Competing Interests: Declaration of Competing Interest The authors deny any conflicts of interest related to this study.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: