Characteristic patterns of SARS-CoV-2 on chest CT suggests a hematologic pathway for viral entry into the lung.

Autor: Salvatore MM; Department of Radiology- Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, NY, United States of America. Electronic address: ms5680@cumc.columbia.edu., Capaccione KM; Department of Radiology- Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, NY, United States of America., Saqi A; Department of Pathology- Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, NY, United States of America., Overdevest JB; Department of Otolaryngology - Head and Neck Surgery, Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, NY, United States of America., Patrizio R; Department of Radiology- Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, NY, United States of America., Gudis DA; Department of Otolaryngology - Head and Neck Surgery, Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, NY, United States of America.
Jazyk: angličtina
Zdroj: Clinical imaging [Clin Imaging] 2022 Sep; Vol. 89, pp. 92-94. Date of Electronic Publication: 2022 Jun 25.
DOI: 10.1016/j.clinimag.2022.06.011
Abstrakt: Many SARS-CoV-2 studies have supported the theory that the Type II alveolar epithelial cells (AEC-2) are the primary portal of entry of the virus into the lung following its brief nasal occupation. However, the theory of inhalational transmission of the virus from the ciliated and goblet nasal cells to the lung parenchyma is not supported by the imaging findings on chest computerized tomography (CT), leading the authors to consider an alternative pathway from the nose to the lung parenchyma that could explain the peripheral, basilar predominant pattern of early disease. Imaging supports that the pulmonary capillaries may be an important vehicle for transmission of the virus and/or associated inflammatory mediators to the lung epithelium.
(Copyright © 2022. Published by Elsevier Inc.)
Databáze: MEDLINE
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