An adaptive teosinte mexicana introgression modulates phosphatidylcholine levels and is associated with maize flowering time.

Autor:	Barnes AC; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695., Rodríguez-Zapata F; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695.; National Laboratory of Genomics for Biodiversity 36821, Irapuato, Mexico., Juárez-Núñez KA; National Laboratory of Genomics for Biodiversity 36821, Irapuato, Mexico., Gates DJ; Department of Evolution and Ecology, Center for Population Biology, and Genome Center, University of California, Davis, CA 95616., Janzen GM; Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA 50011.; Department of Plant Biology, University of Georgia, Athens, GA 30602., Kur A; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695., Wang L; Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA 50011., Jensen SE; US Department of Agriculture-Agricultural Research Service, Cornell University, Ithaca, NY 14853., Estévez-Palmas JM; National Laboratory of Genomics for Biodiversity 36821, Irapuato, Mexico., Crow TM; Department of Plant Sciences, University of California, Davis, CA 95616., Kavi HS; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695., Pil HD; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695., Stokes RL; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695., Knizner KT; Department of Chemistry, North Carolina State University, Raleigh, NC 27695., Aguilar-Rangel MR; National Laboratory of Genomics for Biodiversity 36821, Irapuato, Mexico., Demesa-Arévalo E; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724., Skopelitis T; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724., Pérez-Limón S; National Laboratory of Genomics for Biodiversity 36821, Irapuato, Mexico., Stutts WL; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695.; Molecular Education, Technology and Research Innovation Center, North Carolina State University, Raleigh, NC 27695., Thompson P; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695.; Molecular Education, Technology and Research Innovation Center, North Carolina State University, Raleigh, NC 27695., Chiu YC; Molecular Education, Technology and Research Innovation Center, North Carolina State University, Raleigh, NC 27695., Jackson D; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724., Muddiman DC; Department of Chemistry, North Carolina State University, Raleigh, NC 27695.; Molecular Education, Technology and Research Innovation Center, North Carolina State University, Raleigh, NC 27695., Fiehn O; West Coast Metabolomics Center, University of California, Davis, CA 95618., Runcie D; Department of Plant Sciences, University of California, Davis, CA 95616., Buckler ES; US Department of Agriculture-Agricultural Research Service, Cornell University, Ithaca, NY 14853., Ross-Ibarra J; Department of Evolution and Ecology, Center for Population Biology, and Genome Center, University of California, Davis, CA 95616., Hufford MB; Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA 50011., Sawers RJH; National Laboratory of Genomics for Biodiversity 36821, Irapuato, Mexico.; Department of Plant Science, The Pennsylvania State University, PA 16802., Rellán-Álvarez R; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695.; National Laboratory of Genomics for Biodiversity 36821, Irapuato, Mexico.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jul 05; Vol. 119 (27), pp. e2100036119. Date of Electronic Publication: 2022 Jun 30.
DOI:	10.1073/pnas.2100036119
Abstrakt:	Native Americans domesticated maize ( Zea mays ssp. mays ) from lowland teosinte parviglumis ( Zea mays ssp. parviglumis) in the warm Mexican southwest and brought it to the highlands of Mexico and South America where it was exposed to lower temperatures that imposed strong selection on flowering time. Phospholipids are important metabolites in plant responses to low-temperature and phosphorus availability and have been suggested to influence flowering time. Here, we combined linkage mapping with genome scans to identify High PhosphatidylCholine 1 ( HPC1 ), a gene that encodes a phospholipase A1 enzyme, as a major driver of phospholipid variation in highland maize. Common garden experiments demonstrated strong genotype-by-environment interactions associated with variation at HPC1, with the highland HPC1 allele leading to higher fitness in highlands, possibly by hastening flowering. The highland maize HPC1 variant resulted in impaired function of the encoded protein due to a polymorphism in a highly conserved sequence. A meta-analysis across HPC1 orthologs indicated a strong association between the identity of the amino acid at this position and optimal growth in prokaryotes. Mutagenesis of HPC1 via genome editing validated its role in regulating phospholipid metabolism. Finally, we showed that the highland HPC1 allele entered cultivated maize by introgression from the wild highland teosinte Zea mays ssp. mexicana and has been maintained in maize breeding lines from the Northern United States, Canada, and Europe. Thus, HPC1 introgressed from teosinte mexicana underlies a large metabolic QTL that modulates phosphatidylcholine levels and has an adaptive effect at least in part via induction of early flowering time.
Databáze:	MEDLINE
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